The emerging treatment landscape of targeted therapy in non-small-cell lung cancer

M Yuan, LL Huang, JH Chen, J Wu, Q Xu - Signal transduction and …, 2019 - nature.com
Lung cancer is one of the most common cancer in the world. In 2018, there were over 2
million new cases of lung cancer and over 1.7 million deaths were attributed to lung cancer …

The advance of the third‑generation EGFR‑TKI in the treatment of non‑small cell lung cancer

Z Cheng, H Cui, Y Wang, J Yang, C Lin… - Oncology …, 2023 - spandidos-publications.com
Lung cancer is currently the second most common type of cancer with the second incidence
rate and the first mortality rate worldwide. Non-small cell lung cancer (NSCLC) accounts for …

Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization

M Iwamoto, W Saso, R Sugiyama… - Proceedings of the …, 2019 - National Acad Sciences
Sodium taurocholate cotransporting polypeptide (NTCP) is a host cell receptor required for
hepatitis B virus (HBV) entry. However, the susceptibility of NTCP-expressing cells to HBV is …

Novel quinazoline-based EGFR kinase inhibitors: A review focussing on SAR and molecular docking studies (2015-2019)

P Bhatia, V Sharma, O Alam, A Manaithiya… - European Journal of …, 2020 - Elsevier
The over expression of EGFR has been recognized as the driver mechanism in the
occurrence and progression of carcinomas such as lung cancer, breast cancer, pancreatic …

Applications of nanobodies in brain diseases

F Zheng, Y Pang, L Li, Y Pang, J Zhang… - Frontiers in …, 2022 - frontiersin.org
Nanobodies are antibody fragments derived from camelids, naturally endowed with
properties like low molecular weight, high affinity and low immunogenicity, which contribute …

Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity

DP Byrne, S Shrestha, M Galler, M Cao, LA Daly… - Science …, 2020 - science.org
Reactive oxygen species (ROS) are physiological mediators of cellular signaling and play
potentially damaging roles in human diseases. In this study, we found that the catalytic …

Safety and tolerability of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in oncology

RR Shah, DR Shah - Drug safety, 2019 - Springer
Tyrosine kinase inhibitors (TKIs) that target epidermal growth factor receptor (EGFR) have
dramatically improved progression-free survival in non-small-cell lung cancer (NSCLC) …

Natural tyrosine kinase inhibitors acting on the epidermal growth factor receptor: Their relevance for cancer therapy

Y Liang, T Zhang, J Zhang - Pharmacological Research, 2020 - Elsevier
Epidermal growth factor receptor (EGFR), also known as ErbB-1/HER-1, plays a key role in
the regulation of the cell proliferation, migration, differentiation, and survival. Since the …

Multiple post-translational modifications ensure EGFR functionality: Potential therapeutic targets to overcome its drug-resistance mutations

Q He, M Qu, H Bao, Y Xu, T Shen, D Tan… - Cytokine & Growth …, 2023 - Elsevier
Epidermal growth factor receptor (EGFR) mutation is the most common driver mutation in
non-small cell lung cancer (NSCLC). The first-line therapy for advanced NSCLC patients …

In-silico identification of small molecule benzofuran-1, 2, 3-triazole hybrids as potential inhibitors targeting EGFR in lung cancer via ligand-based pharmacophore …

S Kumar, I Ali, F Abbas, N Khan, MK Gupta… - In Silico …, 2023 - Springer
Lung cancer is one of the most common and deadly types of cancer worldwide, and the
epidermal growth factor receptor (EGFR) has emerged as a promising therapeutic target for …