Diabetic foot ulcer (DFU) is a combination of neuropathy and various degrees of peripheral
vasculopathy in diabetic patients resulting in lower extremity infection, ulcer formation, and …

The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

Angiogenesis Page 1 CHAPTER 42 Angiogenesis JUDAH FOLKMAN I. Introduction
Angiogenesis is the generation of new capillary blood vessels. While all subsequent vessels …

Within the past 2 years, several angiogenic factors have been fully purified, their amino acid
sequences determined, and their genes cloned. These polypeptides include acidic and …

Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in
common certain structural characteristics, and most of whom bind heparin avidly. Many …

Vascular permeability factor (VPF) is an Mr 40-kD protein that has been purified from the
conditioned medium of guinea pig line 10 tumor cells grown in vitro, and increases fluid …

Connective tissue growth factor (CTGF) is a cysteine-rich mitogenic peptide that binds
heparin and is secreted by fibroblasts after activation with transforming growth factor beta …

Publisher Summary The family of fibroblast growth factors (FGF) is the largest family of
growth factors involved in soft–tissue growth and regeneration. The FGF family includes …

I. Introduction B ASIC AND acidic fibroblast growth factors (FGFs) are closely related
molecules that show a similar range of biological activities. They differ, however, in some of …

The mineralized matrix of osseous tissue harbors abundant mitogenic activity which is
extractable by demineralizing solvents. In bovine bone powder free of blood and cartilage …