Chronic low‐grade inflammation in heart failure with preserved ejection fraction

T Mesquita, YN Lin, A Ibrahim - Aging Cell, 2021 - Wiley Online Library
Heart failure (HF) with preserved ejection fraction (HFpEF) is currently the predominant form
of HF with a dramatic increase in risk with age. Low‐grade inflammation, as occurs with …

ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology …

KE Odening, AM Gomez, D Dobrev, L Fabritz… - EP …, 2021 - academic.oup.com
Cardiac arrhythmias are a major cause of death and disability. A large number of
experimental cell and animal models have been developed to study arrhythmogenic …

Nanoengineered electroconductive collagen-based cardiac patch for infarcted myocardium repair

K Hosoyama, M Ahumada, CD McTiernan… - … applied materials & …, 2018 - ACS Publications
We have prepared and tested in vivo a novel nanoengineered hybrid electroconductive
cardiac patch for treating the infarcted myocardium. Of the prepared and tested patches, only …

Mechanisms of sinoatrial node dysfunction in heart failure with preserved ejection fraction

T Mesquita, R Zhang, JH Cho, R Zhang, YN Lin… - Circulation, 2022 - Am Heart Assoc
Background: The ability to increase heart rate during exercise and other stressors is a key
homeostatic feature of the sinoatrial node (SAN). When the physiological heart rate …

Altered Ca2+ and Na+ Homeostasis in Human Hypertrophic Cardiomyopathy: Implications for Arrhythmogenesis

R Coppini, C Ferrantini, A Mugelli, C Poggesi… - Frontiers in …, 2018 - frontiersin.org
Hypertrophic cardiomyopathy (HCM) is the most common mendelian heart disease, with a
prevalence of 1/500. HCM is a primary cause of sudden death, due to an heightened risk of …

Heart failure with preserved ejection fraction: present status and future directions

S Yoon, GH Eom - Experimental & molecular medicine, 2019 - nature.com
The clinical importance of heart failure with preserved ejection fraction (HFpEF) has recently
become apparent. HFpEF refers to heart failure (HF) symptoms with normal or near-normal …

Contributions of inflammation to cardiometabolic heart failure with preserved ejection fraction

EB Thorp, M Filipp - Annual Review of Pathology: Mechanisms …, 2024 - annualreviews.org
The most common form of heart failure is heart failure with preserved ejection fraction
(HFpEF). While heterogeneous in origin, the most common form of HFpEF is the …

Distinct features of calcium handling and β‐adrenergic sensitivity in heart failure with preserved versus reduced ejection fraction

PJ Kilfoil, S Lotteau, R Zhang, X Yue… - The Journal of …, 2020 - Wiley Online Library
Key points Heart failure (HF), the leading cause of death in developed countries, occurs in
the setting of reduced (HFrEF) or preserved (HFpEF) ejection fraction. Unlike HFrEF, there …

Sudden death in heart failure with preserved ejection fraction: a competing risks analysis from the TOPCAT trial

M Vaduganathan, BL Claggett, NA Chatterjee… - JACC: Heart Failure, 2018 - jacc.org
Objectives: This study investigated the rates and predictors of SD or aborted cardiac arrest
(ACA) in HFpEF. Background: Sudden death (SD) may be an important mode of death in …

Prenatal lipopolysaccharides exposure induces transgenerational inheritance of hypertension

N Cao, C Lan, C Chen, Z Xu, H Luo, S Zheng, X Gong… - Circulation, 2022 - Am Heart Assoc
Background: Adverse environmental exposure during the prenatal period can lead to
diseases in the offspring, including hypertension. Whether or not the hypertensive …