The serine protease thrombin, a naturally derived enzyme, plays a key role in hemostasis by
converting fibrinogen to fibrin and activating coagulation factor XIII whereby the fibrin clot is …

Hellmut Hartert was the first person to exploit the viscoelastic properties of clotting blood to
measure blood coagulation in 1948. Since then, the technology has improved, allowing …

Hemorrhage is a major contributor to morbidity and mortality during the perioperative period.
Current methods of diagnosing coagulopathy have various limitations including long …

Hemostasis is a complex physiological mechanism that functions to maintain vascular
integrity under any conditions. Its primary components are blood platelets and a coagulation …

Patients with severe hemophilia A (HA) have an increased risk of spontaneous and trauma‐
related bleeding because of a congenital absence of factor VIII (FVIII). Most severe HA …

Patients with multiple myeloma (MM) are at increased risk of venous thromboembolism.
Therefore, adequate laboratory control of hemostasis and subsequent adjustments of …

Treatment of bleeding and thrombotic disorders is highly standardized and based on
evidence-based medicine guidelines. These evidence-based treatment schemes are well …

Background Heterogeneity in clinical bleeding phenotype has been observed in hemophilia
patients with similar FVIII or FIX activity levels. Thrombin generation and plasmin generation …

Background Treatment choices for individual patients with an inborn bleeding disorder are
increasingly challenging due to increasing options and rising costs for society. We have …

Hemophilia A and B are rare inherited bleeding disorders resulting from deficiency of
coagulation factors VIII and IX respectively. In the past few decades, the field of hemophilia …