As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum
Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the …

Dynapenia (pronounced dahy-nuh-pē-nē-a, Greek translation for poverty of strength, power,
or force) is the age-associated loss of muscle strength that is not caused by neurologic or …

Aging is usually accompanied by a significant reduction in muscle mass and force. To
determine the relative contribution of inactivity and aging per se to this decay, we compared …

The antioxidant enzyme superoxide dismutase 1 (SOD1) is a critical player of the
antioxidative defense whose activity is altered in several chronic diseases, including …

The histologic features of aging muscle suggest that denervation contributes to atrophy, that
immobility accelerates the process, and that routine exercise may protect against loss of …

The deterioration of skeletal muscle with advancing age has long been anecdotally
recognized and has been of scientific interest for more than 150 years. Over the past several …

Sarcopenia is a new type of senile syndrome with progressive skeletal muscle mass loss
with age, accompanied by decreased muscle strength and/or muscle function. Sarcopenia …

Skeletal muscle contraction relies on both high-fidelity calcium (Ca2+) signals and robust
capacity for adenosine triphosphate (ATP) generation. Ca2+ release units (CRUs) are highly …

Abstract Store-operated Ca 2+ entry (SOCE) is a Ca 2+ entry mechanism activated by
depletion of intracellular Ca 2+ stores. In skeletal muscle, SOCE is mediated by an …

Sarcopenia is the degenerative loss of muscle mass and strength with aging. Although a
role of mitochondrial metabolism in muscle function and in the development of many …