Regulatory T cells (Tregs) are central to the maintenance of self-tolerance and tissue
homeostasis. Markers commonly used to define human Tregs in the research setting include …

Infiltration of the lamina propria by inflammatory CD4+ T-cell populations is a key
characteristic of chronic intestinal inflammation. Memory-phenotype CD4+ T-cell frequencies …

Over the past recent years, a great number of studies have been directed toward the
evaluation of the human host–gut microbiota interaction, with the goal to progress the …

Crohn's disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract
responsible for intestinal lesions. The multifactorial etiology attributed to CD includes a …

Background A link between histone deacetylases (HDAC s) and intestinal inflammation has
been established. HDAC inhibitors that target gut‐selective inflammatory pathways …

Inflammatory bowel disease (IBD) is an immune-mediated inflammatory condition causing
inflammation of gastrointestinal and systemic cells, with an increasing prevalence …

Biological treatment with tumor necrosis factor (TNF) inhibitors is successful in the
management of inflammatory bowel disease (IBD). All TNF inhibitors antagonize the pro …

Sarcoidosis is a systemic granulomatous disease that affects numerous organs, commonly
manifesting at the lungs and skin. While corticosteroids remain the first line of treatment …

Autoimmune diseases decrease life expectancy and quality of life for millions of women and
men. Although treatments can slow disease progression and improve quality of life, all …

Treg cells control immune responses to self and nonharmful foreign antigens. Emerging
data from animal models indicate that Treg cells function in both secondary lymphoid organs …