Gut microbiota bridges the iron homeostasis and host health

L Xiao, R Tang, J Wang, D Wan, Y Yin, L Xie - Science China Life …, 2023 - Springer
The gut microbiota acts as a symbiotic microecosystem that plays an indispensable role in
the regulation of a number of metabolic processes in the host by secreting secondary …

Recent advances in the digestive, metabolic and therapeutic effects of farnesoid X receptor and fibroblast growth factor 19: from cholesterol to bile acid signaling

A Di Ciaula, L Bonfrate, J Baj, M Khalil, G Garruti… - Nutrients, 2022 - mdpi.com
Bile acids (BA) are amphiphilic molecules synthesized in the liver (primary BA) starting from
cholesterol. In the small intestine, BA act as strong detergents for emulsification …

Kaempferol ameliorated alcoholic liver disease through inhibiting hepatic bile acid synthesis by targeting intestinal FXR-FGF15 signaling

L Xiao, G Xu, S Chen, Y He, F Peng, C Yuan - Phytomedicine, 2023 - Elsevier
Background Alcoholic liver disease (ALD) is characterized by the disturbance of bile acids
homeostasis, which further deteriorates ALD. Bile acid metabolism and its related signal …

[HTML][HTML] The role of gut microbiota, exosomes, and their interaction in the pathogenesis of ALD

Z Cheng, L Yang, H Chu - Journal of Advanced Research, 2024 - Elsevier
Background The liver disorders caused by alcohol abuse are termed alcoholic-related liver
disease (ALD), including alcoholic steatosis, alcoholic steatohepatitis alcoholic hepatitis …

Postbiotics Prepared Using Lactobacillus reuteri Ameliorates Ethanol‐Induced Liver Injury by Regulating the FXR/SHP/SREBP‐1c Axis

C Liu, T Cai, Y Cheng, J Bai, M Li, B Gu… - Molecular Nutrition & …, 2024 - Wiley Online Library
Scope While probiotics‐based therapies have exhibited potential in alleviating alcohol‐
associated liver disease (ALD), the specific role of postbiotics derived from Lactobacillus …

Hepatocellular carcinoma: Novel understandings and therapeutic strategies based on bile acids

W Luo, S Guo, Y Zhou, J Zhu… - International …, 2022 - spandidos-publications.com
Bile acids (BAs) are the major components of bile and products of cholesterol metabolism.
Cholesterol is catalyzed by a variety of enzymes in the liver to form primary BAs, which are …

High performance anion exchange chromatography purification of probiotic bacterial extracellular vesicles enhances purity and anti‐inflammatory efficacy

NH Pirolli, LSC Reus, Z Mamczarz… - Biotechnology and …, 2023 - Wiley Online Library
Bacterial extracellular vesicles (BEVs), including outer membrane vesicles, have emerged
as a promising new class of vaccines and therapeutics to treat cancer and inflammatory …

Micro Trojan horses: Engineering extracellular vesicles crossing biological barriers for drug delivery

B Zeng, Y Li, J Xia, Y Xiao, N Khan… - Bioengineering & …, 2024 - Wiley Online Library
The biological barriers of the body, such as the blood–brain, placental, intestinal, skin, and
air‐blood, protect against invading viruses and bacteria while providing necessary physical …

Advancements in the alcohol-associated liver disease model

L Zhu, HD Li, JJ Xu, JJ Li, M Cheng, XM Meng… - Biomolecules, 2022 - mdpi.com
Alcohol-associated liver disease (ALD) is an intricate disease that results in a broad
spectrum of liver damage. The presentation of ALD can include simple steatosis …

Liver cirrhosis: molecular mechanisms and therapeutic interventions

Z Dong, Y Wang, W Jin - MedComm, 2024 - Wiley Online Library
Liver cirrhosis is the end‐stage of chronic liver disease, characterized by inflammation,
necrosis, advanced fibrosis, and regenerative nodule formation. Long‐term inflammation …