The public view on antibiotics as reliable medicines changed when reports about “resistant
superbugs” appeared in the news. While reasons for this resistance development are easily …

Interest in protein disulfide bond formation has recently increased because of the prominent
role of disulfide bonds in bacterial virulence and survival. The first discovered pathway that …

Disulfide bonds are important for the stability and function of many secreted proteins. In
Gram-negative bacteria, these linkages are catalyzed by thiol-disulfide oxidoreductases …

In April 2014, the World Health Organization announced the beginning of a post-antibiotic
era and declared antimicrobial resistance (AMR) a public health priority demanding global …

Antibiotic resistance has emerged as a serious threat to global public health in recent years.
Lack of novel antimicrobials, especially new classes of compounds, further aggravates the …

Recent years have witnessed a dramatic increase in bacterial antimicrobial resistance and a
decline in the development of novel antibiotics. New therapeutic strategies are urgently …

Antibiotic resistance is a global health concern that is rapidly spreading among human and
animal pathogens. Developing novel antibiotics is one of the most significant approaches to …

Disulfide Bonds in Protein Folding and Stability | Oxidative Folding of Proteins: Basic
Principles, Cellular Regulation and Engineering | Books Gateway | Royal Society of Chemistry …

Aims: DsbA catalyzes disulfide bond formation in secreted and outer membrane proteins in
bacteria. In pathogens, DsbA is a major facilitator of virulence constituting a target for …

A bottleneck in fragment-based lead development is the lack of systematic approaches to
elaborate the initial fragment hits, which usually bind with low affinity to their target. Herein …