The absorption of oral drugs is frequently plagued by significant variability with potentially
serious therapeutic consequences. The source of variability can be traced back to …

This article reviews the major physiological and physicochemical principles of the effect of
food and gastrointestinal (GI) pH on the absorption and bioavailability of oral drugs, and the …

Food effect, also known as food–drug interactions, is a common phenomenon associated
with orally administered medications and can be defined as changes in absorption rate or …

Many articles have been published in the last two decades demonstrating improvement in
the dissolution and absorption of low solubility drugs when formulated into self-emulsifying …

Purpose To develop physiologically based finite time pharmacokinetic (PBFTPK) models for
the analysis of oral pharmacokinetic data. Methods The models are based on the passive …

Background: Ingestible capsule (IC) systems can assess gastrointestinal (GI) transit times as
a surrogate for gut motility for extended periods of time within a minimally invasive, radiation …

Purpose To explore the application of the parameters of the physiologically based finite time
pharmacokinetic (PBFTPK) models subdivided in first-order (PBFTPK) 1 and zero-order …

The term “disease” conjures a plethora of graphic imagery for many, and the use of drugs to
combat symptoms and treat underlying pathology is at the core of modern medicine …

As a BCS IV drug, ursolic acid (UA) has low oral bioavailability mainly because of its poor
aqueous solubility/dissolution, poor permeability, and metabolism by cytochrome P450 …

Several locally acting colon-targeted products to treat colonic diseases have been recently
developed and marketed, taking advantage of gastrointestinal physiology to target delivery …