The emergence of multidrug resistance (MDR) in malignant tumors is one of the leading
threats encountered currently in many chemotherapeutic agents. The overexpression of the …

Prostate cancer is among most malignant tumors around the world and this urological tumor
can be developed as result of genomic mutations and their accumulation during progression …

Multidrug resistance (MDR) seriously limits the clinical application of chemotherapy. A
mechanism underlying MDR is the overexpression of efflux transporters associated with …

Cancer drug resistance poses a significant obstacle to successful chemotherapy, primarily
driven by the activity of ATP‐binding cassette (ABC) transporters, which actively efflux …

Drug resistance is still an obstacle in cancer therapy, leading to the failure of tumor
treatment. The emergence of tumor drug resistance has always been a main concern of …

Anti-neoplastic agents for cancer treatment utilize many different mechanisms of action and,
when combined, can result in potent inhibition of cancer growth. Combination therapies can …

Drug resistance is perhaps the greatest obstacle in improving outcomes for cancer patients,
leading to recurrence, progression and metastasis of various cancers. Exploring the …

Protein glycosylation is a widespread posttranslational modification that can impact the
function of proteins. Dysregulated protein glycosylation has been linked to several diseases …

Multidrug resistance (MDR) is considered one of the significant chemotherapy failures of
cancer patients and resulting in tumor recurrence and refractory cancer. The collateral …

Brevilin A (BA), a sesquiterpene lactone isolated from Centipeda minima herb, has been
identified to exhibit potent anticancer activity. However, the potential pharmacological effect …