Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells
Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a
promising treatment for diabetes. Despite progress in the generation of stem-cell-derived …
promising treatment for diabetes. Despite progress in the generation of stem-cell-derived …
Modelling the endocrine pancreas in health and disease
Diabetes mellitus is a multifactorial disease affecting increasing numbers of patients
worldwide. Progression to insulin-dependent diabetes mellitus is characterized by the loss …
worldwide. Progression to insulin-dependent diabetes mellitus is characterized by the loss …
β-Cell maturation and identity in health and disease
C Salinno, P Cota, A Bastidas-Ponce… - International journal of …, 2019 - mdpi.com
The exponential increase of patients with diabetes mellitus urges for novel therapeutic
strategies to reduce the socioeconomic burden of this disease. The loss or dysfunction of …
strategies to reduce the socioeconomic burden of this disease. The loss or dysfunction of …
[HTML][HTML] Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease
Population-level variation and mechanisms behind insulin secretion in response to
carbohydrate, protein, and fat remain uncharacterized. We defined prototypical insulin …
carbohydrate, protein, and fat remain uncharacterized. We defined prototypical insulin …
XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice
Aims/hypothesis Pancreatic beta cell dedifferentiation, transdifferentiation into other islet
cells and apoptosis have been implicated in beta cell failure in type 2 diabetes, although the …
cells and apoptosis have been implicated in beta cell failure in type 2 diabetes, although the …
Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles
RB Kang, Y Li, C Rosselot, T Zhang, M Siddiq… - Genome Medicine, 2023 - Springer
Background Single-cell RNA sequencing (scRNA-seq) provides valuable insights into
human islet cell types and their corresponding stable gene expression profiles. However …
human islet cell types and their corresponding stable gene expression profiles. However …
Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice
C Dos Santos, A Cambraia, S Shrestha… - Nature …, 2024 - nature.com
Caloric restriction (CR) can extend the organism life-and health-span by improving glucose
homeostasis. How CR affects the structure-function of pancreatic beta cells remains …
homeostasis. How CR affects the structure-function of pancreatic beta cells remains …
[HTML][HTML] Single-cell transcriptome profiling of mouse and hESC-derived pancreatic progenitors
Human embryonic stem cells (hESCs) are a potential unlimited source of insulin-producing
β cells for diabetes treatment. A greater understanding of how β cells form during embryonic …
β cells for diabetes treatment. A greater understanding of how β cells form during embryonic …
Modulation of insulin sensitivity by insulin-degrading enzyme
CM González-Casimiro, B Merino… - Biomedicines, 2021 - mdpi.com
Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed
metalloprotease that degrades insulin and several other intermediate-size peptides. For …
metalloprotease that degrades insulin and several other intermediate-size peptides. For …
IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
The islet in type 2 diabetes (T2D) is characterized by amyloid deposits derived from islet
amyloid polypeptide (IAPP), a protein co-expressed with insulin by β-cells. In common with …
amyloid polypeptide (IAPP), a protein co-expressed with insulin by β-cells. In common with …