The blood–brain barrier in systemic infection and inflammation
I Galea - Cellular & molecular immunology, 2021 - nature.com
The vascular blood–brain barrier is a highly regulated interface between the blood and
brain. Its primary function is to protect central neurons while signaling the presence of …
brain. Its primary function is to protect central neurons while signaling the presence of …
Strategies for delivering therapeutics across the blood–brain barrier
GC Terstappen, AH Meyer, RD Bell… - Nature Reviews Drug …, 2021 - nature.com
Achieving sufficient delivery across the blood–brain barrier is a key challenge in the
development of drugs to treat central nervous system (CNS) disorders. This is particularly …
development of drugs to treat central nervous system (CNS) disorders. This is particularly …
Blood-brain barrier dysfunction amplifies the development of neuroinflammation: understanding of cellular events in brain microvascular endothelial cells for …
F Takata, S Nakagawa, J Matsumoto… - Frontiers in cellular …, 2021 - frontiersin.org
Neuroinflammation is involved in the onset or progression of various neurodegenerative
diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage …
diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage …
The blood–brain barrier and blood–tumour barrier in brain tumours and metastases
CD Arvanitis, GB Ferraro, RK Jain - Nature Reviews Cancer, 2020 - nature.com
For a blood-borne cancer therapeutic agent to be effective, it must cross the blood vessel
wall to reach cancer cells in adequate quantities, and it must overcome the resistance …
wall to reach cancer cells in adequate quantities, and it must overcome the resistance …
Physiological blood–brain transport is impaired with age by a shift in transcytosis
The vascular interface of the brain, known as the blood–brain barrier (BBB), is understood to
maintain brain function in part via its low transcellular permeability,–. Yet, recent studies …
maintain brain function in part via its low transcellular permeability,–. Yet, recent studies …
Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions
MP McGinley, JA Cohen - The Lancet, 2021 - thelancet.com
Summary The sphingosine 1-phosphate (S1P) signalling pathways have important and
diverse functions. S1P receptors (S1PRs) have been proposed as a therapeutic target for …
diverse functions. S1P receptors (S1PRs) have been proposed as a therapeutic target for …
[HTML][HTML] Emerging roles of lysophospholipids in health and disease
ST Tan, T Ramesh, XR Toh, LN Nguyen - Progress in Lipid Research, 2020 - Elsevier
Lipids are abundant and play essential roles in human health and disease. The main
functions of lipids are building blocks for membrane biogenesis. However, lipids are also …
functions of lipids are building blocks for membrane biogenesis. However, lipids are also …
Alzheimer's disease: a matter of blood–brain barrier dysfunction?
The blood–brain barrier (BBB) keeps neurotoxic plasma-derived components, cells, and
pathogens out of the brain. An early BBB breakdown and/or dysfunction have been shown in …
pathogens out of the brain. An early BBB breakdown and/or dysfunction have been shown in …
Astrocytes are necessary for blood–brain barrier maintenance in the adult mouse brain
BP Heithoff, KK George, AN Phares, IA Zuidhoek… - Glia, 2021 - Wiley Online Library
In the adult brain, multiple cell types are known to produce factors that regulate blood–brain
barrier (BBB) properties, including astrocytes. Yet several recent studies disputed a role for …
barrier (BBB) properties, including astrocytes. Yet several recent studies disputed a role for …