TNF in the liver: targeting a central player in inflammation

G Tiegs, AK Horst - Seminars in immunopathology, 2022 - Springer
Tumour necrosis factor-α (TNF) is a multifunctional cytokine. First recognized as an
endogenous soluble factor that induces necrosis of solid tumours, TNF became increasingly …

Autoimmmune hepatitis

B Terziroli Beretta-Piccoli, G Mieli-Vergani… - Cellular & molecular …, 2022 - nature.com
Autoimmune hepatitis (AIH) is a T-cell mediated, inflammatory liver disease affecting all
ages and characterized by female preponderance, elevated serum transaminase and …

Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation

B Wu, TV Zhao, K Jin, Z Hu, MP Abdel… - Nature …, 2021 - nature.com
Misdirected immunity gives rise to the autoimmune tissue inflammation of rheumatoid
arthritis, in which excess production of the cytokine tumor necrosis factor (TNF) is a central …

Metabolic reprogramming of the intestinal microbiome with functional bile acid changes underlie the development of NAFLD

E Smirnova, MD Muthiah, N Narayan, MS Siddiqui… - Hepatology, 2022 - journals.lww.com
Autoimmune hepatitis (AIH) is a rare disease of unclear etiology characterized by loss of self‐
tolerance that can lead to liver injury, cirrhosis, and acute liver failure. First‐line treatment …

[PDF][PDF] Noninvasive biomarkers for the diagnosis and management of autoimmune hepatitis

C Harrington, S Krishnan, CL Mack, P Cravedi… - …, 2022 - Wiley Online Library
Autoimmune hepatitis (AIH) is a rare disease of unclear etiology characterized by loss of self‐
tolerance that can lead to liver injury, cirrhosis, and acute liver failure. First‐line treatment …

T helper cell immunity in pregnancy and influence on autoimmune disease progression

JJ Graham, MS Longhi, MA Heneghan - Journal of autoimmunity, 2021 - Elsevier
Pregnancy presents the maternal immune system with a unique immunological challenge
since it has to defend against pathogens while tolerating paternal allo-antigens expressed …

Regulatory T cells in autoimmune hepatitis: unveiling their roles in mouse models and patients

H Wang, X Feng, W Yan, D Tian - Frontiers in Immunology, 2020 - frontiersin.org
Autoimmune hepatitis (AIH) is a severe and chronic liver disease, and its incidence has
increased worldwide in recent years. Research into the pathogenesis of AIH remains limited …

[HTML][HTML] CD4+ T-cell subsets in autoimmune hepatitis: A review

H Chen, Z Han, Y Fan, L Chen, F Peng… - Hepatology …, 2023 - journals.lww.com
Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease that can lead to
hepatocyte destruction, inflammation, liver fibrosis, cirrhosis, and liver failure. The diagnosis …

Research gaps and opportunities in autoimmune hepatitis—Results of the international autoimmune hepatitis group research workshop 2022

RJ Snijders, DN Assis, YH Oo, M Sebode… - Liver …, 2023 - Wiley Online Library
Autoimmune hepatitis (AIH) is a rare autoimmune liver disease that is characterised by a
chronic inflammatory immune reaction directed against hepatocytes. The disease results in …

Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis

A Renand, I Cervera-Marzal, L Gil, C Dong… - Journal of …, 2020 - Elsevier
Background & Aims In most autoimmune disorders, crosstalk of B cells and CD4 T cells
results in the accumulation of autoantibodies. In autoimmune hepatitis (AIH), the presence of …