Hypoxia, low oxygen (O2) level, is a hallmark of solid cancers, especially hepatocellular
carcinoma (HCC), one of the most common and fatal cancers worldwide. Hypoxia …

Altered energy metabolism is a hallmark of tumors aiming at supplying necessary nutrients
for tumorigenesis and development. These redirected metabolic pathways associated with …

Abstract Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …

Hepatocellular carcinoma (HCC) invariably exhibits inadequate O2 (hypoxia) and nutrient
supply. Hypoxia-inducible factor (HIF) mediates cascades of molecular events that enable …

Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC).
However, the development of drug resistance is common. By using genome-wide …

In most cases, sorafenib-resistant HCC cells exhibit significant mesenchymal phenotype and
stemness features. In this context, tumor cells might undergo cell fate transition in response …

Background & Aims Hepatocellular carcinoma (HCC) is a highly aggressive malignancy with
dreadful clinical outcome. Tyrosine kinase inhibitors and immune checkpoint inhibitors are …

Background Feed contributes most to livestock production costs. Improving feed efficiency is
crucial to increase profitability and sustainability for animal production. Host genetics and …

Hypoxia is commonly found in cancers. Hypoxia, due to the lack of oxygen (O2) as the
electron recipient, causes inefficient electron transfer through the electron transport chain at …

The nuclear factor erythroid 2-related factor 2 (NRF2)–Kelch-like ECH-associated protein 1
(KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from …