Anti-diabetic, anti-bacterial and anti-oxidant potential of new biologically active thiazole-derivatives: Experimental and molecular docking studies
In this study, we synthesised and characterised a series of thiazole derivatives (compounds
3a–j) and assessed their potential for anti-diabetic, anti-bacterial and anti-oxidant activities …
3a–j) and assessed their potential for anti-diabetic, anti-bacterial and anti-oxidant activities …
Design, Synthesis, and In Vitro Cytotoxic Studies of Some Novel Arylidene-Hydrazinyl-Thiazoles as Anticancer and Apoptosis-Inducing Agents
Cancer, defined by uncontrolled cell growth, poses a significant global health challenge,
necessitating the development of new anticancer drugs crucial to address drug resistance …
necessitating the development of new anticancer drugs crucial to address drug resistance …
Novel sulfonamide-tethered Schiff bases as anti-proliferative agents with VEGFR-2 inhibitory activity: Synthesis, biological assessment, and molecular dynamic …
Schiff bases tethered with sulfonamide functionality (6a-l) are reported as potential
anticancer agents and apoptotic inducers. The anti-proliferative activities of the tested Schiff …
anticancer agents and apoptotic inducers. The anti-proliferative activities of the tested Schiff …
Modulation of transcription profile induced by antiproliferative thiosemicarbazone metal complexes in U937 cancer cells
S Montalbano, F Bisceglie, G Pelosi, M Lazzaretti… - Pharmaceutics, 2023 - mdpi.com
Since the discovery of cisplatin, the search for metal-based compounds with therapeutic
potential has been a challenge for the scientific community. In this landscape …
potential has been a challenge for the scientific community. In this landscape …
Synthesis, anti-diabetic profiling and molecular docking studies of 2-(2-arylidenehydrazinyl)thiazol-4(5H)-ones
Aim: To synthesize novel more potent anti-diabetic agents. Methodology: A simple cost
effective Hantzsch's synthetic strategy was used to synthesize 2-(2-arylidenehydrazinyl) …
effective Hantzsch's synthetic strategy was used to synthesize 2-(2-arylidenehydrazinyl) …
Synthesis of Substituted Arylidene Hydrazinyl Trifluoromethyl Thiazole Derivatives and their Antibacterial Studies using different Genes Expression
Cyclization of substituted thiosemicarbazones with 3‐bromo‐1, 1, 1‐trifluoroacetone affords
new 2‐(arylidenehydrazinyl)‐4‐trifluoromethylthiazoles (3 a–m, 13 examples, 71–89%) …
new 2‐(arylidenehydrazinyl)‐4‐trifluoromethylthiazoles (3 a–m, 13 examples, 71–89%) …
Synthesis of hydrazinyl–thiazole ester derivatives, in vitro trypanocidal and leishmanicidal activities
Aim: To synthesize novel more potent trypanocidal and leishmanicidal agents. Methods:
Hantzsch's synthetic strategy was used to synthesize 1, 3-thiazole-4-carboxylates and their …
Hantzsch's synthetic strategy was used to synthesize 1, 3-thiazole-4-carboxylates and their …
Synthesis, Molecular Docking, and Anticancer Screening of Ester‐Based Thiazole Derivatives
M Musa, M Bello, EC Agwamba - Chemistry & Biodiversity, 2024 - Wiley Online Library
This study investigates the potential of five compounds as novel anticancer agents. We
examined their efficacy, mechanisms of action, and impact on various cancer cell lines …
examined their efficacy, mechanisms of action, and impact on various cancer cell lines …