CD40 is a TNF receptor superfamily member expressed on both immune and non-immune
cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L …

Immune checkpoint inhibitor therapy has revolutionized the treatment of advanced
malignancies in recent years. Numerous reports have detailed the myriad of possible …

Transplantation is the only curative treatment for patients with kidney failure but it poses
unique immunological challenges that must be overcome to prevent allograft rejection and …

Atherosclerosis is a major underlying cause of cardiovascular disease. Previous studies
showed that inhibition of the co-stimulatory CD40 ligand (CD40L)-CD40 signaling axis …

Simple Summary CD40 is a costimulatory molecule that is key for the activation of antigen-
presenting cells and other innate immune cells. It plays an important role in anti-tumor …

Cardiovascular disease (CVD), which encompasses a number of conditions that can affect
the heart and blood vessels, presents a major challenge for modern-day healthcare. Nearly …

Immune-inflammatory conditions in the central nervous system (CNS) rely on molecular and
cellular interactions which are homeostatically maintained to protect neural tissue from …

CD39/NTPDase1 has emerged as an important molecule that contributes to maintain
inflammatory and coagulatory homeostasis. Various studies have hypothesized the possible …

Cardiovascular disease remains the main cause of death worldwide. For this reason,
strategies for the primary prevention of atherosclerosis and atherosclerosis-related …

The leading cause of heart disease in developed countries is coronary atherosclerosis,
which is not simply a result of ageing but a chronic inflammatory process that can lead to …