The evolution of gene expression in cis and trans
SA Signor, SV Nuzhdin - Trends in Genetics, 2018 - cell.com
There is abundant variation in gene expression between individuals, populations, and
species. The evolution of gene regulation and expression within and between species is …
species. The evolution of gene regulation and expression within and between species is …
Genetics of complex traits: prediction of phenotype, identification of causal polymorphisms and genetic architecture
ME Goddard, KE Kemper… - … of the Royal …, 2016 - royalsocietypublishing.org
Complex or quantitative traits are important in medicine, agriculture and evolution, yet, until
recently, few of the polymorphisms that cause variation in these traits were known. Genome …
recently, few of the polymorphisms that cause variation in these traits were known. Genome …
Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tract
The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show
that cigarette smoke causes a dose-dependent upregulation of angiotensin converting …
that cigarette smoke causes a dose-dependent upregulation of angiotensin converting …
Genomes of the mouse collaborative cross
Abstract The Collaborative Cross (CC) is a multiparent panel of recombinant inbred (RI)
mouse strains derived from eight founder laboratory strains. RI panels are popular because …
mouse strains derived from eight founder laboratory strains. RI panels are popular because …
The mouse universal genotyping array: from substrains to subspecies
Genotyping microarrays are an important resource for genetic mapping, population genetics,
and monitoring of the genetic integrity of laboratory stocks. We have developed the third …
and monitoring of the genetic integrity of laboratory stocks. We have developed the third …
The landscape of genomic imprinting across diverse adult human tissues
Genomic imprinting is an important regulatory mechanism that silences one of the parental
copies of a gene. To systematically characterize this phenomenon, we analyze tissue …
copies of a gene. To systematically characterize this phenomenon, we analyze tissue …
[HTML][HTML] SNPsplit: Allele-specific splitting of alignments between genomes with known SNP genotypes
F Krueger, SR Andrews - F1000Research, 2016 - ncbi.nlm.nih.gov
Sequencing reads overlapping polymorphic sites in diploid mammalian genomes may be
assigned to one allele or the other. This holds the potential to detect gene expression …
assigned to one allele or the other. This holds the potential to detect gene expression …
The transcription factor Foxp3 shapes regulatory T cell identity by tuning the activity of trans-acting intermediaries
Regulatory T (Treg) cell identity is defined by the lineage-specifying transcription factor (TF)
Foxp3. Here we examined mechanisms of Foxp3 function by leveraging naturally occurring …
Foxp3. Here we examined mechanisms of Foxp3 function by leveraging naturally occurring …
Sex-and age-dependent genetics of longevity in a heterogeneous mouse population
DNA variants that modulate life span provide insight into determinants of health, disease,
and aging. Through analyses in the UM-HET3 mice of the Interventions Testing Program …
and aging. Through analyses in the UM-HET3 mice of the Interventions Testing Program …
A unified atlas of CD8 T cell dysfunctional states in cancer and infection
CD8 T cells play an essential role in defense against viral and bacterial infections and in
tumor immunity. Deciphering T cell loss of functionality is complicated by the conspicuous …
tumor immunity. Deciphering T cell loss of functionality is complicated by the conspicuous …