[HTML][HTML] Enduring neurobiological consequences of early-life stress: Insights from rodent behavioral paradigms

L Speranza, KD Filiz, P Lippiello, MG Ferraro… - Biomedicines, 2024 - mdpi.com
Stress profoundly affects physical and mental health, particularly when experienced early in
life. Early-life stress (ELS) encompasses adverse childhood experiences such as abuse …

Early life adversity across different cell-types in the brain

G Warhaftig, D Almeida, G Turecki - Neuroscience & Biobehavioral …, 2023 - Elsevier
Early life adversity (ELA)-which includes physical, psychological, emotional, and sexual
abuse is one of the most common predictors to diverse psychopathologies later in …

[HTML][HTML] Barrier–environment interactions along the gut–brain axis and their influence on cognition and behaviour throughout the lifespan

SEJ Paton, JL Solano, F Coulombe-Rozon… - Journal of Psychiatry and …, 2023 - jpn.ca
Environment is known to substantially alter mental state and behaviour across the lifespan.
Biological barriers such as the blood–brain barrier (BBB) and gut barrier (GB) are major …

Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression in Caenorhabditiselegans

T Kyani-Rogers, A Philbrook, IG McLachlan… - Genetics, 2022 - academic.oup.com
Developmental experiences play critical roles in shaping adult physiology and behavior. We
and others previously showed that adult Caenorhabditis elegans which transiently …

Fluoxetine treatment supports predictive validity of the three hit model of depression in male PACAP heterozygous mice and underpins the impact of early life adversity …

T Gaszner, J Farkas, D Kun, B Ujvári, G Berta… - Frontiers in …, 2022 - frontiersin.org
According to the three hit concept of depression, interaction of genetic predisposition altered
epigenetic programming and environmental stress factors contribute to the disease. Earlier …

Activation of somatostatin neurons in the medial amygdala reverses long-term aggression and social deficits associated to early-life stress in male mice

A Mañas-Ojeda, J Hidalgo-Cortés… - Molecular …, 2024 - nature.com
Early postnatal development is a critical period for the configuration of neural networks that
support social and affective-like behaviors. In this sense, children raised in stressful …

PRESENCE d'une Prédisposition: Premier épisode d'une série de huit épisodes sur le cerveau

CF Fahmy - Cortica, 2022 - revue-cortica.net
Résumé L'objectif du modèle PRESENCE est de mettre en lumière les connaissances sur le
développement du cerveau au service des neurosciences de l'éducation. PRESENCE …

[HTML][HTML] Neurobiological Mechanisms Underlying Psychological Dysfunction After Brain Injuries

P Unadkat, T Rebeiz, E Ajmal, V De Souza, A Xia… - Cells, 2025 - mdpi.com
Despite the presentation of similar psychological symptoms, psychological dysfunction
secondary to brain injury exhibits markedly lower treatment efficacy compared to injury …

Epigenetic Aging in Major Depressive Disorder: Clocks, Mechanisms and Therapeutic Perspectives

M Shaikh, G Doshi - European Journal of Pharmacology, 2024 - Elsevier
Depression, a chronic mental disorder characterized by persistent sadness, loss of interest,
and difficulty in daily tasks, impacts millions globally with varying treatment options …

Involvement of oxytocin receptor deficiency in psychiatric disorders and behavioral abnormalities

J Wei, H Zheng, G Li, Z Chen, G Fang… - Frontiers in Cellular …, 2023 - frontiersin.org
Oxytocin and its target receptor (oxytocin receptor, OXTR) exert important roles in the
regulation of complex social behaviors and cognition. The oxytocin/OXTR system in the …