Simple Summary Cell migration is crucial fReaor metastasis formation and a hallmark of
malignancy. The primary cause of high mortality among oncology patients is the ability of …

Calcium (Ca2+) plays an important role in regulating the differentiation and function of
osteoclasts. Calcium oscillations (Ca oscillations) are well-known phenomena in receptor …

Osteoclast differentiation and function are critical targets for anti-osteoporosis treatment.
Oxidative stress also plays an important regulatory role in the differentiation of osteoclasts …

Introduction To study human physiological and pathological bone remodeling while
addressing the principle of replacement, reduction and refinement of animal experiments …

In the ageing skeleton, the balance of bone reconstruction could commonly be broken by the
increasing of bone resorption and decreasing of bone formation. Consequently, the bone …

Abnormal stress loading has been considered a major contributor to the initiation of
temporomandibular joint osteoarthritis (TMJOA), but studies to date have not identified a …

Cells are known to perceive their microenvironment through extracellular and intracellular
mechanical signals. Upon sensing mechanical stimuli, cells can initiate various downstream …

Osteoclast signatures are determined by two transcriptional programs, the lineage-
determining transcription pathway and the receptor activator of nuclear factor kappa-B …

Rationale: Stem cells self-organize to form organoids that generate mini-organs that
resemble the physiologically-developed ones. The mechanism by which the stem cells …

The cellular response to the extracellular matrix (ECM) microenvironment mediated by
integrin adhesion is of fundamental importance, in both developmental and pathological …