Multinucleation is a hallmark of osteoclast maturation. The unique and dynamic
multinucleation process not only increases cell size but causes functional alterations …

The morbidity and mortality associated with fractures due to osteoporosis or “porous bone”
contributes significantly to global healthcare costs and will increase exponentially with …

Paracrine signaling by bone-marrow-derived mesenchymal stem cells (MSCs) plays a major
role in tissue repair. Although the production of regulatory cytokines by MSC transplantation …

Osteoblastic bone formation and osteoclastic bone resorption dynamically maintain the
bone homeostasis; in the present study, we attempt to investigate the mechanism of the …

Bone is a dynamic organ continuously undergoing shaping, repairing and remodeling. The
homeostasis of bone is maintained by the balance between osteoblastic bone formation and …

Lung cancer is a kind of malignant tumor with rapid progression and poor prognosis. Distant
metastasis has been the main cause of mortality among lung cancer patients. Bone is one of …

The objective of this study is to design a graphene‐based miRNA transfection drug delivery
system for antiresorptive therapy. An efficient nonviral gene delivery system is developed …

Mesenchymal stem cells (MSCs) have the potential to reduce healing time and treat
nonunion in fracture patients. In this study, bone marrow MSCs-derived extracellular …

In bone remodeling, after a lifespan of∼ 2 weeks, osteoclasts undergo apoptosis in each
bone turnover cycle, resulting in generation of a large number of apoptotic bodies (ABs) …

Acute liver injury has multiple causes and can result in liver failure. In this study, we
evaluated the hepatoprotective ability of cyanidin (Cy) and investigated its associated …