Psoriasis is a chronic autoimmune inflammatory disease characterized by erroneous
metabolism of keratinocytes. The development of psoriasis is closely related to abnormal …

Intervertebral disc degeneration (IDD) and associated conditions are an important problem
in modern medicine. The onset of IDD may be in childhood and adolescence in patients with …

Rheumatoid arthritis (RA) is a chronic autoimmune disease that has not been completely
treated for a long time. Therefore, effective therapy for RA is still urgently needed at present …

Inducible nitric oxide synthase (iNOS) and vascular endothelial dysfunction have been
implicated in the development and progression of atherosclerosis. This study aimed to …

Importance Psoriasis is an inflammatory condition associated with metabolic and
cardiovascular disease. Apremilast, a phosphodiesterase 4 inhibitor, is commonly used for …

For decades, topical corticosteroids have been the mainstay of treatment for mild-to-
moderate inflammatory skin diseases, even though only short-term use is approved for these …

3′, 5′-cyclic adenosine monophosphate (cAMP) is a second messenger critically involved
in the control of a myriad of processes with significant implications for vascular and cardiac …

Increasing evidence suggests a role of neuroinflammation in substance use disorders
(SUDs). This Review presents findings from neuroimaging studies assessing brain markers …

As a life-threatening disorder, sepsis-associated lung injury is a dysregulated inflammatory
response to microbial infection, characterized by the infiltration of inflammatory cells into …

Extravasation of T cells from the bloodstream into inflamed tissues requires interactions
between T cells and vascular endothelial cells, a necessary step that allows T cells to exert …