The aim of this ESC Guideline is to help health professionals manage people with heart
failure (HF) according to the best available evidence. Fortunately, we now have a wealth of …

Uric acid (UA) is synthesized mainly in the liver, intestines, and vascular endothelium as the
end product of an exogenous purine from food and endogenously from damaged, dying …

Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …

Abstract Document Reviewers: Rudolf A. de Boer (CPG Review Coordinator)(Netherlands),
P. Christian Schulze (CPG Review Coordinator)(Germany), Magdy Abdelhamid (Egypt) …

Objective To develop recommendations for cardiovascular risk (CVR) management in gout,
vasculitis, systemic sclerosis (SSc), myositis, mixed connective tissue disease (MCTD) …

Objective To provide guidance for the management of gout, including indications for and
optimal use of urate‐lowering therapy (ULT), treatment of gout flares, and lifestyle and other …

Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

Background Allopurinol is a urate-lowering therapy used to treat patients with gout. Previous
studies have shown that allopurinol has positive effects on several cardiovascular …

Uric acid (UA) is the end product of purine nucleotide metabolism in the human body.
Hyperuricemia is an abnormally high level of UA in the blood and may result in arthritis and …

Uric acid, the end-product of purine metabolism in humans, is not only a cause of gout, but
also may play roles in developing cardiovascular diseases such as hypertension, atrial …