With the increasing use of genomic profiling for diagnosis and therapy guidance in many
tumor types, precision oncology is rapidly reshaping cancer care. However, the current …

Purpose Recent years have seen a change in the way that clinical trials are being
conducted. There has been a rise of designs more flexible than traditional adaptive and …

Control of CRISPR/Cas12a trans-cleavage is crucial for biosensor development. Here, we
show that small circular DNA nanostructures which partially match guide RNA sequences …

Purpose To determine the safety and efficacy of PARP plus PD-L1 inhibition (olaparib+
durvalumab, O+ D) in patients with advanced solid, predominantly rare cancers harbouring …

Precision cancer medicine is a multidisciplinary team effort that requires involvement and
commitment of many stakeholders including the society at large. Building on the success of …

Abstract The Dutch Drug Rediscovery Protocol (DRUP) and the Australian Cancer Molecular
Screening and Therapeutic (MoST) Program are similar nonrandomized, multidrug, pan …

Precision medicine approaches that inform clinical management of individuals with cancer
are progressively advancing. Patient-derived explants (PDEs) provide a patient-proximal ex …

Cancer is a genetic disease. To date, translational cancer genomics has focused largely on
somatic alterations, driven by the desire to identify targets for personalized therapy …

Rare cancers, which collectively account for almost 25% of all malignancies, are poorly
understood in terms of their aetiology and pathogenesis and are infrequently the focus of …

For rare cancers, challenges in establishing standard therapies are greater than those for
major cancers, and effective methods are needed. MASTER KEY Project is a multicenter …