Anti-inflammatory drugs have been prescribed extensively for a wide range of diseases.
Combined with over-the-counter use, approximately 30 billion doses of non-steroidal …

Background: Nanocrystallization technologies have been widely studied in recent years, as
the formulation of drug nanocrystals solves problems of poor drug solubility and …

Rutin is a polyphenolic flavonoid with an interestingly wide therapeutic spectrum. However,
its clinical benefits are limited by its poor aqueous solubility and low bioavailability. In an …

Present study was aimed to increase the oral bioavailability and reduce the fast fed
variability of Ibrutinib by developing nanosuspension by simple precipitation-ultrasonication …

Clinical significance of Rutin (RUT) is limited by poor dissolution rate and low oral
bioavailability. The study was designed to improve the physicochemical and therapeutic …

Poor aqueous solubility leading to poor oral bioavailability is a bottle neck in the
development of many new drug candidates; particularly the BCS class II-IV drugs. These …

Combinational therapy has become increasingly popular in recent times due to various
advantages like greater therapeutic effect, reduced number of prescriptions, lower …

Glibenclamide (GLB), which belongs to Class-II (BCS), has poor oral bioavailability
attributable to its insufficient aqueous solubility. The study's major goal was to manufacture …

Gliclazide (GCZ), an antidiabetic medication, has poor solubility and limited oral
bioavailability due to substantial first-pass metabolism. Thus, the purpose of the current …

The present work embarks upon increasing the dissolution rate and the bioavailability of
model anti-diabetic drug, gliquidone, a sulfonylurea class drug used for treating diabetes …