On the cellular and network bases of epileptic seizures

DA McCormick, D Contreras - Annual review of physiology, 2001 - annualreviews.org
▪ Abstract The highly interconnected networks of the mammalian forebrain can generate a
wide variety of synchronized activities, including those underlying epileptic seizures, which …

Selective vulnerability of the hippocampus in brain ischemia

R Schmidt-Kastner, TF Freund - Neuroscience, 1991 - Elsevier
Selective vulnerability of the hippocampus in brain ischemia - ScienceDirect Skip to main
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[图书][B] Neuronal networks of the hippocampus

RD Traub, R Miles - 1991 - books.google.com
The questions of how a large population of neurons in the brain functions, how synchronized
firing of neurons is achieved, and what factors regulate how many and which neurons fire …

Erratum to “Cellular mechanisms underlying acquired epilepsy: the calcium hypothesis of the induction and maintenance of epilepsy”[Pharmacol. Ther. 105 (3)(2005) …

RJ DeLorenzo, DA Sun, LS Deshpande - Pharmacology & therapeutics, 2006 - Elsevier
Epilepsy is one of the most common neurological disorders. Although epilepsy can be
idiopathic, it is estimated that up to 50% of all epilepsy cases are initiated by neurological …

Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus

ZI Bashir, S Alford, SN Davies, AD Randall… - Nature, 1991 - nature.com
NEUROTRANSMISSION at most excitatory synapses in the brain operates through two
types of glutamate receptor termed α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate …

How long do new‐onset seizures in children last?

S Shinnar, AT Berg, SL Moshe… - Annals of neurology, 2001 - Wiley Online Library
Although there are data on the duration of seizures in patients with refractory epilepsy, little
is known about the duration of seizures in nonrefractory epilepsy populations. In a …

Molecular signaling mechanisms underlying epileptogenesis

JO McNamara, YZ Huang, AS Leonard - Science's STKE, 2006 - science.org
Epilepsy, a disorder of recurrent seizures, is a common and frequently devastating
neurological condition. Available therapy is only symptomatic and often ineffective …

In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures

I Khalilov, GL Holmes, Y Ben-Ari - Nature neuroscience, 2003 - nature.com
We have determined whether seizures generate an epileptogenic focus in distal structures
using an in vitro preparation composed of three independent chambers that accommodate …

Plasticity of hippocampal excitatory‐inhibitory balance: Missing the synaptic control in the epileptic brain

C Bonansco, M Fuenzalida - Neural plasticity, 2016 - Wiley Online Library
Synaptic plasticity is the capacity generated by experience to modify the neural function and,
thereby, adapt our behaviour. Long‐term plasticity of glutamatergic and GABAergic …

Decreased glutamate receptor 2 expression and enhanced epileptogenesis in immature rat hippocampus after perinatal hypoxia-induced seizures

RM Sanchez, S Koh, C Rio, C Wang… - Journal of …, 2001 - Soc Neuroscience
Hypoxic encephalopathy is the most common cause of neonatal seizures and can lead to
chronic epilepsy. In rats at postnatal days 10–12 (P10–12), global hypoxia induces …