Much of our knowledge on K+-channels was elucidated using specific peptide ligands
isolated from a number of venomous organisms. Recently, this field received a strong …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by demyelination, with a relative sparing of axons. In MS patients, many …

Animal toxins acting on ion channels of excitable cells are principally highly potent short
peptides that are present in limited amounts in the venoms of various unrelated species …

Potassium (K+) channels are a widespread superfamily of integral membrane proteins that
mediate selective transport of K+ ions through the cell membrane. They have been found in …

OSK1 (α-KTx3. 7) is a 38-residue toxin cross-linked by three disulphide bridges that was
initially isolated from the venom of the Asian scorpion Orthochirus scrobiculosus. OSK1 and …

During the last two decades since the identification and characterization of T cell potassium
channels great advances have been made in the understanding of the role of these …

Abstracts Voltage-gated K+ channels (K v) play an important role in regulating contraction of
vascular smooth muscle cells (VSMC) through their effects on membrane potential and on …

Snake venom serine proteases (SVSPs) are complex and multifunctional enzymes, acting
primarily on hemostasis. In this work, we report the hitherto unknown inhibitory effect of a …

Abstract Kalium (http://kaliumdb. org/) is a manually curated database that accumulates data
on potassium channel toxins purified from scorpion venom (KTx). This database is an open …

This review categorizes functionally validated actions of defined scorpion toxin (SCTX)
neuropeptides across ion channel subclasses, highlighting key trends in this rapidly …