Phage display as a tool for vaccine and immunotherapy development

KL Hess, CM Jewell - Bioengineering & translational medicine, 2020 - Wiley Online Library
Bacteriophages, or phages, are viruses that specifically infect bacteria and coopt the cellular
machinery to create more phage proteins, eventually resulting in the release of new phage …

A historical review of military medical strategies for fighting infectious diseases: From battlefields to global health

R Biselli, R Nisini, F Lista, A Autore, M Lastilla… - Biomedicines, 2022 - mdpi.com
The environmental conditions generated by war and characterized by poverty,
undernutrition, stress, difficult access to safe water and food as well as lack of environmental …

Enzootic Plague Reduces Black-Footed Ferret (Mustela nigripes) Survival in Montana

MR Matchett, DE Biggins, V Carlson… - Vector-Borne and …, 2010 - liebertpub.com
Black-footed ferrets (Mustela nigripes) require extensive prairie dog colonies (Cynomys
spp.) to provide habitat and prey. Epizootic plague kills both prairie dogs and ferrets and is a …

Effective plague vaccination via oral delivery of plant cells expressing F1-V antigens in chloroplasts

PA Arlen, M Singleton, JJ Adamovicz, Y Ding… - Infection and …, 2008 - Am Soc Microbiol
The chloroplast bioreactor is an alternative to fermentation-based systems for production of
vaccine antigens and biopharmaceuticals. We report here expression of the plague F1-V …

Mutated and Bacteriophage T4 Nanoparticle Arrayed F1-V Immunogens from Yersinia pestis as Next Generation Plague Vaccines

P Tao, M Mahalingam, ML Kirtley, CJ van Lier… - PLoS …, 2013 - journals.plos.org
Pneumonic plague is a highly virulent infectious disease with 100% mortality rate, and its
causative organism Yersinia pestis poses a serious threat for deliberate use as a bioterror …

Adhesive organelles of Gram-negative pathogens assembled with the classical chaperone/usher machinery: structure and function from a clinical standpoint

V Zav'yalov, A Zavialov, G Zav'yalova… - FEMS microbiology …, 2010 - academic.oup.com
This review summarizes current knowledge on the structure, function, assembly and
biomedical applications of the superfamily of adhesive fimbrial organelles exposed on the …

Encapsulation into amphiphilic polyanhydride microparticles stabilizes Yersinia pestis antigens

B Carrillo-Conde, E Schiltz, J Yu, FC Minion… - Acta biomaterialia, 2010 - Elsevier
The design of biodegradable polymeric delivery systems based on polyanhydrides that
would provide for improved structural integrity of Yersinia pestis antigens was the main goal …

Multi-Functional Characteristics of the Pseudomonas aeruginosa Type III Needle-Tip Protein, PcrV; Comparison to Orthologs in other Gram-negative Bacteria

H Sato, DW Frank - Frontiers in microbiology, 2011 - frontiersin.org
Pseudomonas aeruginosa possesses a type III secretion system (T3SS) to intoxicate host
cells and evade innate immunity. This virulence-related machinery consists of a molecular …

Prevention of pneumonic plague in mice, rats, guinea pigs and non-human primates with clinical grade rV10, rV10-2 or F1-V vaccines

LE Quenee, NA Ciletti, D Elli, TM Hermanas… - Vaccine, 2011 - Elsevier
Yersinia pestis causes plague, a disease with high mortality in humans that can be
transmitted by fleabite or aerosol. A US Food and Drug Administration (FDA)-licensed …

Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague

Y Do, H Koh, CG Park, D Dudziak, P Seo… - European journal of …, 2010 - Wiley Online Library
To help design needed new vaccines for pneumonic plague, we targeted the Yersinia pestis
LcrV protein directly to CD8α+ DEC‐205+ or CD8α− DCIR2+ DC along with a clinically …