Structures and mechanisms in the cGAS-STING innate immunity pathway
Besides its role as the blueprint of life, DNA can also alert the cell to the presence of
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …
Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across
AK Minnaert, H Vanluchene, R Verbeke… - Advanced drug delivery …, 2021 - Elsevier
The recent approval of messenger RNA (mRNA)-based vaccines to combat the SARS-CoV-
2 pandemic highlights the potential of both conventional mRNA and self-amplifying mRNA …
2 pandemic highlights the potential of both conventional mRNA and self-amplifying mRNA …
cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila
KM Slavik, BR Morehouse, AE Ragucci, W Zhou, X Ai… - Nature, 2021 - nature.com
Abstract Cyclic GMP–AMP synthase (cGAS) is a cytosolic DNA sensor that produces the
second messenger cG [2′–5′] pA [3′–5′] p (2′ 3′-cGAMP) and controls activation of …
second messenger cG [2′–5′] pA [3′–5′] p (2′ 3′-cGAMP) and controls activation of …
cGLRs are a diverse family of pattern recognition receptors in innate immunity
Y Li, KM Slavik, HC Toyoda, BR Morehouse… - Cell, 2023 - cell.com
Summary Cyclic GMP-AMP synthase (cGAS) is an enzyme in human cells that controls an
immune response to cytosolic DNA. Upon binding DNA, cGAS synthesizes a nucleotide …
immune response to cytosolic DNA. Upon binding DNA, cGAS synthesizes a nucleotide …
Bacterial cGAS-like enzymes synthesize diverse nucleotide signals
Cyclic dinucleotides (CDNs) have central roles in bacterial homeostasis and virulence by
acting as nucleotide second messengers. Bacterial CDNs also elicit immune responses …
acting as nucleotide second messengers. Bacterial CDNs also elicit immune responses …
cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans
The metazoan cGAMP-activated cGAS–STING innate immunity pathway is triggered in
response to genomic instability and DNA damage, thereby providing host defense against …
response to genomic instability and DNA damage, thereby providing host defense against …
Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling
AM Burroughs, D Zhang, DE Schäffer… - Nucleic acids …, 2015 - academic.oup.com
Cyclic di-and linear oligo-nucleotide signals activate defenses against invasive nucleic
acids in animal immunity; however, their evolutionary antecedents are poorly understood …
acids in animal immunity; however, their evolutionary antecedents are poorly understood …
Dance with the devil: stress granules and signaling in antiviral responses
N Eiermann, K Haneke, Z Sun, G Stoecklin, A Ruggieri - Viruses, 2020 - mdpi.com
Cells have evolved highly specialized sentinels that detect viral infection and elicit an
antiviral response. Among these, the stress-sensing protein kinase R, which is activated by …
antiviral response. Among these, the stress-sensing protein kinase R, which is activated by …
HORMA domain proteins and a Trip13-like ATPase regulate bacterial cGAS-like enzymes to mediate bacteriophage immunity
Bacteria are continually challenged by foreign invaders, including bacteriophages, and have
evolved a variety of defenses against these invaders. Here, we describe the structural and …
evolved a variety of defenses against these invaders. Here, we describe the structural and …
Ribosome• RelA structures reveal the mechanism of stringent response activation
AB Loveland, E Bah, R Madireddy, Y Zhang, AF Brilot… - Elife, 2016 - elifesciences.org
Stringent response is a conserved bacterial stress response underlying virulence and
antibiotic resistance. RelA/SpoT-homolog proteins synthesize transcriptional modulators (p) …
antibiotic resistance. RelA/SpoT-homolog proteins synthesize transcriptional modulators (p) …