Progress in acute myeloid leukaemia treatment is occurring at an unprecedented pace. The
past decade has witnessed an increasingly improved scientific understanding of the …

Bone marrow (BM) is a highly complex tissue that provides important regulatory signals to
orchestrate hematopoiesis. Resident and transient cells occupy and interact with some well …

Extramedullary deposits of acute myeloid leukemia (eAML), constitute an unusual
presentation or complication of AML, which can occur in isolation (isolated eAML) or in the …

Extramedullary (EM) colonization is a rare complication of acute myeloid leukemia (AML),
occurring in about 10% of patients, but the processes underlying tissue invasion are not …

Backgrounds The incidence of extramedullary diseases (EMDs) in patients diagnosed with
acute myeloid leukemia (AML) is approximately 10–20%. These patients exhibit a …

The role of the vascular microenvironment is increasingly studied in acute myeloid
leukaemia (AML). Complex interactions between endothelial cells (ECs) and pre-leukaemic …

Increased bone marrow (BM) homing of NK cells is associated with positive outcome in
patients with acute myeloid leukemia (AML) treated within adoptive NK cell transfer trials …

Simple Summary Extramedullary presentation of acute myeloid leukemia is a rare event that
can occur at diagnosis or at relapse, together or independent of bone marrow involvement …

Chronic myeloid leukemia (CML) is a slow-growing type of cancer that originates in the
blood-forming cells of the bone marrow and is caused by a chromosomal mutation that is …

Summary Interferon regulatory factor 8 (IRF8) is a member of the IRF family that is specific to
the hematopoietic cell and is involved in regulating the development of human monocytic …