Over the past 25 years, the role of nitric oxide (NO) in biology has evolvedfrom being
recognized as an environmental pollutant to an endogenously produced substance involved …

In the past 5 years, nitric oxide (NO) has become recognized as a major player in most
physiological and pathophysiological processes. So much has been learned about the …

Vascular endothelial growth factor (VEGF) is a regulator of vasculogenesis and
angiogenesis. To investigate the role of nitric oxide (NO) in VEGF-induced proliferation and …

Estradiol retards the development of atherosclerosis. Animal models have suggested that
NO may be a critical effector molecule in this cardiovascular protection. In this study, female …

Estrogen induces both rapid and delayed effects on the cardiovascular system. The early
effects take place within minutes (eg, changes in vasomotor tone) and are mediated through …

A growing body of evidence suggests that hydrogen sulfide (H2S) is a signaling molecule in
mammalian cells. In the cardiovascular system, H2S enhances vasodilation and …

We analyzed the influence of aging and genetic hypertension on the function and
expression of soluble guanylyl cyclase (sGC) in the aortas of prehypertensive and old …

Abstract Objective/Methods: Genetic hypertension is associated with an apparent
endothelial dysfunction and impaired endothelium-dependent vasodilatation in response to …

Estradiol (E 2) causes endothelium-dependent vasodilation, mediated, in part, by enhanced
nitric oxide (NO) release. We have previously shown that E 2-induced activation of …

Soluble guanylate cyclase (sGC) is a receptor for nitric oxide (NO). Binding of NO to ferrous
(Fe 2+) heme increases its catalytic activity, leading to the production of cGMP from GTP …