Bacterial chromosome organization and segregation

A Badrinarayanan, TBK Le… - Annual review of cell and …, 2015 - annualreviews.org
If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long,
approximately 1,000 times the length of a cell. Not only must cells massively compact their …

Types and functions of heterogeneity in mycobacteria

ES Chung, WC Johnson, BB Aldridge - Nature Reviews Microbiology, 2022 - nature.com
The remarkable ability of Mycobacterium tuberculosis to survive attacks from the host
immune response and drug treatment is due to the resilience of a few bacilli rather than a …

Nucleoid associated proteins: the small organizers that help to cope with stress

J Hołówka, J Zakrzewska-Czerwińska - Frontiers in microbiology, 2020 - frontiersin.org
The bacterial chromosome must be efficiently compacted to fit inside the small and crowded
cell while remaining accessible for the protein complexes involved in replication …

The roles of nucleoid-associated proteins and topoisomerases in chromosome structure, strand segregation, and the generation of phenotypic heterogeneity in …

V Norris, C Kayser, G Muskhelishvili… - FEMS Microbiology …, 2023 - academic.oup.com
How to adapt to a changing environment is a fundamental, recurrent problem confronting
cells. One solution is for cells to organize their constituents into a limited number of spatially …

Ser/Thr phosphorylation as a regulatory mechanism in bacteria

J Dworkin - Current opinion in microbiology, 2015 - Elsevier
Highlights•Ser/Thr phosphorylation is involved in the regulation of cell wall synthesis and
translation.•Ser/Thr kinases phosphorylate elements of two-component systems.•Ser/Thr …

Nucleoid-associated protein HU: A lilliputian in gene regulation of bacterial virulence

P Stojkova, P Spidlova, J Stulik - Frontiers in cellular and infection …, 2019 - frontiersin.org
Nucleoid-associated proteins belong to a group of small but abundant proteins in bacterial
cells. These transcription regulators are responsible for many important cellular processes …

Metagenomic profiling of soil microbes to mine salt stress tolerance genes

V Ahmed, MK Verma, S Gupta, V Mandhan… - Frontiers in …, 2018 - frontiersin.org
Osmotolerance is one of the critical factors for successful survival and colonization of
microbes in saline environments. Nonetheless, information about these osmotolerance …

Role of eukaryotic-like serine/threonine kinases in bacterial cell division and morphogenesis

S Manuse, A Fleurie, L Zucchini… - FEMS microbiology …, 2016 - academic.oup.com
Bacteria possess a repertoire of versatile protein kinases modulating diverse aspects of their
physiology by phosphorylating proteins on various amino acids including histidine, cysteine …

Lysine acetylation of the Mycobacterium tuberculosis HU protein modulates its DNA binding and genome organization

S Ghosh, B Padmanabhan, C Anand… - Molecular …, 2016 - Wiley Online Library
Nucleoid‐associated protein HU, a conserved protein across eubacteria is necessary for
maintaining the nucleoid organization and global regulation of gene expression …

The two-component system WalKR provides an essential link between cell wall homeostasis and DNA replication in Staphylococcus aureus

LKR Sharkey, R Guerillot, CJ Walsh, AM Turner… - Mbio, 2023 - Am Soc Microbiol
Among the 16 two-component systems in the opportunistic human pathogen
Staphylococcus aureus, only WalKR is essential. Like the orthologous systems in other …