SOX genes and their role in disorders of sex development
R Sreenivasan, N Gonen, A Sinclair - Sexual Development, 2022 - karger.com
SOX genesare master regulatory genes controlling development and are fundamental to the
establishment of sex determination in a multitude of organisms. The discovery of the master …
establishment of sex determination in a multitude of organisms. The discovery of the master …
Targeting the non-coding genome for the diagnosis of disorders of sex development
G Atlas, R Sreenivasan, A Sinclair - Sexual Development, 2021 - karger.com
Disorders of sex development (DSD) are a complex group of conditions with highly variable
clinical phenotypes, most often caused by failure of gonadal development. DSD are …
clinical phenotypes, most often caused by failure of gonadal development. DSD are …
Functional analysis of SRY variants in individuals with 46, XY Differences of Sex Development.
FP Idris, J van den Bergen, G Robevska… - Molecular and Cellular …, 2025 - Elsevier
In mammals, male sexual development is initiated by the expression of the Sex-determining-
Region-Y (SRY) gene. SRY contains a highly conserved High Mobility Group (HMG) box …
Region-Y (SRY) gene. SRY contains a highly conserved High Mobility Group (HMG) box …
[HTML][HTML] Role of nucleobase-specific interactions in the binding and bending of DNA by human male sex determination factor SRY
JD Racca, YS Chen, AR Brabender, U Battistin… - Journal of Biological …, 2024 - Elsevier
Y-chromosome–encoded master transcription factor SRY functions in the embryogenesis of
therian mammals to initiate male development. Through interactions of its conserved high …
therian mammals to initiate male development. Through interactions of its conserved high …
[HTML][HTML] Tenuous transcriptional threshold of human sex determination. II. SRY exploits water-mediated clamp at the edge of ambiguity
Y-encoded transcription factor SRY initiates male differentiation in therian mammals. This
factor contains a high-mobility-group (HMG) box, which mediates sequence-specific DNA …
factor contains a high-mobility-group (HMG) box, which mediates sequence-specific DNA …
Tenuous transcriptional threshold of human sex determination. i. sry and swyer syndrome at the edge of ambiguity
Male sex determination in mammals is initiated by SRY, a Y-encoded transcription factor.
The protein contains a high-mobility-group (HMG) box mediating sequence-specific DNA …
The protein contains a high-mobility-group (HMG) box mediating sequence-specific DNA …
[PDF][PDF] Tenuous Transcriptional Threshold of Human Sex Determination. I
The male phenotype in therian mammals is determined by Sry1 (designated SRY in
primates), an architectural transcription factor encoded by the pseudo-autosomal region of …
primates), an architectural transcription factor encoded by the pseudo-autosomal region of …