The high mobility group A (HMGA) non-histone chromatin proteins alter chromatin structure
and thereby regulate the transcription of several genes by either enhancing or suppressing …

The mammalian HMGI/Y (HMGA) non-histone proteins participate in a wide variety of
cellular processes including regulation of inducible gene transcription, integration of …

The structural characteristics of the three nuclear phosphoproteins of the high mobility group
A family are outlined and related to their participation in chromatin structure alteration in …

Lung cancer is still the leading cause of death from cancer worldwide primarily because of
the fact that most lung cancers are diagnosed at advanced stages. Overexpression of the …

Numerous studies have demonstrated that overexpression or aberrant expression of the
HMGI (Y) family of architectural transcription factors is frequently associated with both …

Overexpression of the HMGA2 gene is a common feature of neoplastic cells both in
experimental and human models. Intragenic and extragenic HMGA2 rearrangements …

Background & Objectives: Chromatin structure is the single most important feature that
distinguishes a cancer cell from a normal cell histologically. Chromatin remodeling proteins …

High mobility group A (HMGA) proteins play an important role in the regulation of
transcription, differentiation, and neoplastic transformation. In this work, the expression of …

Long-standing studies have clearly established that the architectural chromatinic proteins
High Mobility Group A (HMGA) are among the most widely expressed cancer-associated …

The HMGA2 protein belongs to the HMGA family of architectural transcription factors, which
play an important role in chromatin organization. HMGA proteins are overexpressed in …