The cilium evolved to provide the ancestral eukaryote with the ability to move and sense its
environment. Acquiring these functions required the compartmentalization of a dynein …

Primary cilia play counterregulatory roles in cystogenesis—they inhibit cyst formation in the
normal renal tubule but promote cyst growth when the function of polycystins is impaired …

The orphan G protein-coupled receptor (GPCR) GPR161 plays a central role in
development by suppressing Hedgehog signaling. The fundamental basis of how GPR161 …

Primary cilia on granule cell neuron progenitors in the developing cerebellum detect sonic
hedgehog to facilitate proliferation. Following differentiation, cerebellar granule cells …

A fundamental problem in tissue morphogenesis is identifying how subcellular signaling
regulates mesoscale organization of tissues. The primary cilium is a paradigmatic organelle …

Mammalian phospholipase D (PLD) enzyme family consists of six members. Among them,
PLD1/2/6 catalyzes phosphatidic acid (PA) production, while PLD3/4/5 has no catalytic …

The primary cilium is a hair-like sensory compartment that protrudes from the cellular
surface. The primary cilium is enriched in a variety of signaling molecules that regulate …

The role of compartmentalized signaling in primary cilia during tissue morphogenesis is not
well understood. The cilia localized G protein-coupled receptor, Gpr161, represses …

Hedgehog (Hh) signaling, an evolutionarily conserved pathway, plays an essential role in
development and tumorigenesis, making it a promising drug target. Multiple negative …

The primary cilium constitutes an organelle that orchestrates signal transduction
independently from the cell body. Dysregulation of this intricate molecular architecture leads …