Orofacial clefts embryology, classification, epidemiology, and genetics
G Nasreddine, J El Hajj… - … Research/Reviews in …, 2021 - Elsevier
Orofacial clefts (OFCs) rank as the second most common congenital birth defect in the
United States after Down syndrome and are the most common head and neck congenital …
United States after Down syndrome and are the most common head and neck congenital …
Facial genetics: a brief overview
Historically, craniofacial genetic research has understandably focused on identifying the
causes of craniofacial anomalies and it has only been within the last 10 years, that there has …
causes of craniofacial anomalies and it has only been within the last 10 years, that there has …
Multimodal spatiotemporal transcriptomic resolution of embryonic palate osteogenesis
The terminal differentiation of osteoblasts and subsequent formation of bone marks an
important phase in palate development that leads to the separation of the oral and nasal …
important phase in palate development that leads to the separation of the oral and nasal …
Decoding the human face: progress and challenges in understanding the genetics of craniofacial morphology
Variations in the form of the human face, which plays a role in our individual identities and
societal interactions, have fascinated scientists and artists alike. Here, we review our current …
societal interactions, have fascinated scientists and artists alike. Here, we review our current …
Revisiting the embryogenesis of lip and palate development
NL Hammond, MJ Dixon - Oral Diseases, 2022 - Wiley Online Library
Clefts of the lip and palate (CLP), the major causes of congenital facial malformation
globally, result from failure of fusion of the facial processes during embryogenesis. With a …
globally, result from failure of fusion of the facial processes during embryogenesis. With a …
High-resolution epigenomic atlas of human embryonic craniofacial development
Defects in patterning during human embryonic development frequently result in craniofacial
abnormalities. The gene regulatory programs that build the craniofacial complex are likely …
abnormalities. The gene regulatory programs that build the craniofacial complex are likely …
Genetics and signaling mechanisms of orofacial clefts
Craniofacial development involves several complex tissue movements including several
fusion processes to form the frontonasal and maxillary structures, including the upper lip and …
fusion processes to form the frontonasal and maxillary structures, including the upper lip and …
Assessment of candidate genes and genetic heterogeneity in human non syndromic orofacial clefts specifically non syndromic cleft lip with or without palate
Non syndromic orofacial clefts specifically non-syndromic cleft lip/palate are one of the most
common craniofacial malformation among birth defects in human having multifactorial …
common craniofacial malformation among birth defects in human having multifactorial …
Genome-wide enrichment of de novo coding mutations in orofacial cleft trios
MR Bishop, KKD Perez, M Sun, S Ho, P Chopra… - The American Journal of …, 2020 - cell.com
Although de novo mutations (DNMs) are known to increase an individual's risk of congenital
defects, DNMs have not been fully explored regarding orofacial clefts (OFCs), one of the …
defects, DNMs have not been fully explored regarding orofacial clefts (OFCs), one of the …
Whole exome sequencing identifies mutations in 10% of patients with familial non-syndromic cleft lip and/or palate in genes mutated in well-known syndromes
Background Oral clefts, that is, clefts of the lip and/or cleft palate (CL/P), are the most
common craniofacial birth defects with an approximate incidence of~ 1/700. To date …
common craniofacial birth defects with an approximate incidence of~ 1/700. To date …