Genotoxicity has been identified as the main cause of infertility and a variety of cancers. The
mechanisms affect the structure, quality of the information or the segregation of DNA and are …

Simple Summary The accumulated evidence on the role of epigenetic markers of prognosis
in clear cell renal cell carcinoma (ccRCC) is reviewed, as well as state of the art on …

Zinc finger myeloid, nervy, and deformed epidermal autoregulatory factor 1-type containing
8 (Zinc finger MYND-type containing 8, ZMYND8) is a transcription factor, a histone H3 …

Rearrangement of the 1q12 pericentromeric heterochromatin and subsequent amplification
of the 1q arm is commonly associated with cancer development and progression and may …

Heterochromatin is a transcriptionally repressive chromatin architecture that has a low
abundance of genes but an enrichment of transposons. Defects in heterochromatin can …

Glioblastoma multiforme (GBM) is a fatal brain tumor without effective drug treatment. In this
study, we highlight, for the first time, the contribution of chromatin remodeling gene Lysine …

Simple Summary Recently, PRUNE2 mutations were indicated in the pathogenesis of
aggressive parathyroid neoplasms. Here, we report novel, rare PRUNE2 mutations located …

Renal cell carcinoma accounts for 2–3% of all cancers. It is difficult to diagnose early.
Recently, genome-wide studies have identified that histone methylation was one of the …

目的· 研究失活的蛋白赖氨酸去甲基化酶5C (lysine demethylase 5C, KDM5C)
对肾透明细胞癌迁移, 侵袭的作用, 分析它调控的基因, 探索其失活后促癌的机制. 方法 …

Clear cell renal cell carcinoma (ccRCC) is curable when diagnosed at an early stage, but
when disease is non-confined it is the urologic cancer with worst prognosis. Antiangiogenic …