SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs,
occasionally causing death. Until effective vaccines are developed to curb the pandemic, it …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the loss of
self-tolerance and formation of nuclear autoantigens and immune complexes resulting in …

The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …

The Janus kinase/signal transduction and activator of transcription (JAK–STAT) signaling
pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases …

The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway
plays critical roles in orchestrating of immune system, especially cytokine receptors and they …

Increased risk of premature cardiovascular disease (CVD) is well recognized in systemic
lupus erythematosus (SLE). Aberrant type I-Interferon (IFN)-neutrophil interactions contribute …

Neutrophil extracellular traps (NETs) are fibrous networks which protrude from the
membranes of activated neutrophils. NETs are found in a variety of conditions such as …

The four Janus kinase (JAK) proteins and the seven Signal Transducers of Activated
Transcription (STAT) mediate intracellular signal transduction downstream of cytokine …

Cytokines play a central role in the pathophysiology of autoimmune and inflammatory
diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized …

Systemic lupus erythematosus (SLE) is a chronic multi-organ debilitating autoimmune
disease, which mainly afflicts women in the reproductive years. A complex interaction of …