Hyperpolarized NMR Spectroscopy: d‐DNP, PHIP, and SABRE Techniques

KV Kovtunov, EV Pokochueva… - Chemistry–An Asian …, 2018 - Wiley Online Library
The intensity of NMR signals can be enhanced by several orders of magnitude by using
various techniques for the hyperpolarization of different molecules. Such approaches can …

Hyperpolarized water as universal sensitivity booster in biomolecular NMR

C Hilty, D Kurzbach, L Frydman - Nature protocols, 2022 - nature.com
NMR spectroscopy is the only method to access the structural dynamics of biomolecules at
high (atomistic) resolution in their native solution state. However, this method's low …

Practical dissolution dynamic nuclear polarization

SJ Elliott, Q Stern, M Ceillier, T El Daraï… - Progress in Nuclear …, 2021 - Elsevier
This review article intends to provide insightful advice for dissolution-dynamic nuclear
polarization in the form of a practical handbook. The goal is to aid research groups to …

Application and methodology of dissolution dynamic nuclear polarization in physical, chemical and biological contexts

S Jannin, JN Dumez, P Giraudeau… - Journal of Magnetic …, 2019 - Elsevier
Dissolution dynamic nuclear polarization (d-DNP) is a versatile method to enhance nuclear
magnetic resonance (NMR) spectroscopy. It boosts signal intensities by four to five orders of …

Hyperpolarization via dissolution dynamic nuclear polarization: new technological and methodological advances

AC Pinon, A Capozzi, JH Ardenkjær-Larsen - … Resonance Materials in …, 2021 - Springer
Dissolution-DNP is a method to boost liquid-state NMR sensitivity by several orders of
magnitude. The technique consists in hyperpolarizing samples by solid-state dynamic …

Frémy's salt as a low-persistence hyperpolarization agent: efficient dynamic nuclear polarization plus rapid radical scavenging

M Negroni, E Turhan, T Kress, M Ceillier… - Journal of the …, 2022 - ACS Publications
Nuclear magnetic resonance (NMR) spectroscopy is a key technique for molecular structure
determination in solution. However, due to its low sensitivity, many efforts have been made …

Design and performance of a small bath cryostat with NMR capability for transport of hyperpolarized samples

A Capozzi - Scientific Reports, 2022 - nature.com
As of today, dissolution Dynamic Nuclear Polarization (dDNP) is the only clinically available
hyperpolarization technique for 13C-MRI. Despite the clear path towards personalized …

Scalable dissolution-dynamic nuclear polarization with rapid transfer of a polarized solid

K Kouřil, H Kouřilová, S Bartram, MH Levitt… - Nature …, 2019 - nature.com
In dissolution-dynamic nuclear polarization, nuclear spins are hyperpolarized at cryogenic
temperatures using radicals and microwave irradiation. The hyperpolarized solid is …

Hyperpolarized water through dissolution dynamic nuclear polarization with UV-generated radicals

AC Pinon, A Capozzi… - Communications Chemistry, 2020 - nature.com
In recent years, hyperpolarization of water protons via dissolution Dynamic Nuclear
Polarization (dDNP) has attracted increasing interest in the magnetic resonance community …

[HTML][HTML] An automated system for fast transfer and injection of hyperpolarized solutions

M Ceillier, O Cala, T El Daraï, SF Cousin… - Journal of Magnetic …, 2021 - Elsevier
Dissolution dynamic nuclear polarization (dDNP) has become a hyperpolarization method of
choice for enhancing nuclear magnetic resonance (NMR) signals. Nuclear spins are …