Conspectus With unparalleled programmability, DNA has evolved as a powerful scaffold for
engineering intricate and dynamic systems that can perform diverse tasks. By allowing serial …

Risk of cancer especially of colon, breast, and pancreas is high in diabetic and obese
patients, with potential involvement of augmented expression of RAGE (receptor for …

Ninety-seven percent of drug-indication pairs that are tested in clinical trials in oncology
never advance to receive US Food and Drug Administration approval. While lack of efficacy …

Abstract Analysis of publicly available genomic and gene expression data demonstrates that
MCL1 expression is frequently elevated in breast cancer. Distinct from other pro-survival Bcl …

The induced expansion of tumor‐initiating cells (T‐ICs) upon repeated exposure of tumors to
chemotherapeutic drugs forms a major cause for chemoresistance and cancer metastasis …

Better knowledge of the tumor genomic landscapes has helped to develop more effective
targeted drugs. However, there is no tool to interpret targetability of genomic alterations …

In breast cancer, humoral immune responses may contribute to clinical outcomes, especially
in more immunogenic subtypes. Here, we investigated B lymphocyte subsets …

Triple negative breast cancer (TNBC) a clinically aggressive subtype of breast cancer with
poor outcomes. Chromosomal instability is a hallmark of many TNBCs, and likely underlies …

The NanoString RNA counting assay for formalin-fixed paraffin embedded samples is
unique in its sensitivity, technical reproducibility and robustness for analysis of clinical and …

PIM (proviral integration site for moloney murine leukemia virus) kinase plays a key role as
an oncogene in various cancers including myeloma, leukemia, prostate and breast cancers …