Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and
produce aggressive malignancies that causes millions of deaths every year. With the new …

Heteroatoms as well as heterocyclic scaffolds are frequently present as the common cores in
a plethora of active pharmaceuticals natural products. Statistically, more than 85% of all …

Methotrexate (MTX) is the first line drug for the treatment of a number of rheumatic and non-
rheumatic disorders. It is currently used as an anchor disease, modifying anti-rheumatic drug …

It has been appreciated for nearly 100 years that cancer cells are metabolically distinct from
resting tissues. More recently understood is that this metabolic phenotype is not unique to …

Developing effective lymph-node (LN) targeting and imaging probes is crucial for the early
detection and diagnosis of tumor metastasis to improve patient survival. Most current clinical …

Highlights•Dendrimers are nanovectors with well-defined architecture and tunable surface
characteristics.•Dendrimers can take advantage of passive and active tumor targeting for …

The interest in using the polymer-coated gold nanoparticles (P-AuNPs) for various
biomedical applications, including the delivery of chemotherapeutic in cancer has been …

Methotrexate (MTX), the gold standard against psoriasis, poses severe problems when
administered systemically viz increased toxicity, poor solubility and adverse reactions …

Natural products have made significant contribution to cancer chemotherapy over the past
decades and remain an indispensable source of molecular and mechanistic diversity for …

Glioblastoma (GBM) is the most lethal form of brain tumor, being characterized by the rapid
growth and invasion of the surrounding tissue. The current standard treatment for …