Tumour-associated macrophages (TAMs) are crucial components of the tumour
microenvironment and play a significant role in tumour development and drug resistance by …

Osteosarcoma (OS) is the most common primary malignancy of the bone and has a high
propensity for local invasion and metastasis. Although combining surgery with …

Metabolic reprogramming enables cancer cell growth, proliferation, and survival. This
reprogramming is driven by the combined actions of oncogenic alterations in cancer cells …

Targeting tumor cell metabolism is an attractive form of therapy, as it may enhance treatment
response in therapy resistant cancers as well as mitigate treatment-related toxicities by …

The reprogramming of a patient's immune system through genetic modification of the T cell
compartment with chimeric antigen receptors (CARs) has led to durable remissions in …

Arginase is a key hydrolase in the urea cycle that hydrolyses L-arginine to urea and L-
ornithine. Increasing number of studies in recent years demonstrate that two mammalian …

Immune cells survey and patrol throughout the body and sometimes take residence in niche
environments with distinct cellular subtypes and nutrients that may fluctuate from those in …

The tumor microenvironment (TME) is a major contributor to cancer malignancy including
development of therapeutic resistance, a process mediated in part through intercellular …

Rationale: Synergic reprogramming of metabolic dominates neuroblastoma (NB)
progression. It is of great clinical implications to develop an individualized risk …

Diffuse intrinsic pontine glioma (DIPG) is an incurable malignant childhood brain tumor, with
no active systemic therapies and a 5-year survival of less than 1%. Polyamines are small …