Abstracts Bone mainly functions as a supportive framework for the whole body and is the
major regulator of calcium homeostasis and hematopoietic function. Recently, an increasing …

Postmenopausal osteoporosis (PMOP) is a prevalent skeletal disorder associated with
menopause-related estrogen withdrawal. PMOP is characterized by low bone mass …

Mesenchymal stem cells (MSCs) give rise to adipocytes, osteocytes, and chondrocytes and
reside in various tissues, including bone marrow and adipose tissue. The differentiation …

The skeleton is diverse in its functions, which include mechanical support, movement, blood
cell production, mineral storage and endocrine regulation. This multifaceted role is achieved …

Recent advances in our understanding of blood vessels and vascular niches in bone convey
their critical importance in regulating bone development and physiology. The contribution of …

Acute myeloid leukemias (AML) comprise a wide array of different entities, which have in
common a rapid expansion of myeloid blast cells leading to displacement of normal …

Monocytes play a key role in the development of metabolic syndrome, and especially
obesity. Given the complex features of their development from progenitor cells, whose …

The bone marrow is home to well-balanced normal hematopoiesis, but also the stage of
leukemia's crime. Marrow adipose tissue (MAT) is a unique and versatile component of the …

Maintaining the correct proportions of different cell types in the bone marrow is critical for
bone function. Hypertrophic chondrocytes (HCs) and osteoblasts are a lineage continuum …

Fracture healing is a complex, multistep process that is highly sensitive to mechanical
signaling. To optimize repair, surgeons prescribe immediate weight-bearing as-tolerated …