[HTML][HTML] The molecular athlete: exercise physiology from mechanisms to medals

R Furrer, JA Hawley, C Handschin - Physiological Reviews, 2023 - journals.physiology.org
Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

[HTML][HTML] Fusion and beyond: Satellite cell contributions to loading‐induced skeletal muscle adaptation

KA Murach, CS Fry, EE Dupont‐Versteegden… - The FASEB …, 2021 - ncbi.nlm.nih.gov
Satellite cells support adult skeletal muscle fiber adaptations to loading in numerous ways.
The fusion of satellite cells, driven by cell‐autonomous and/or extrinsic factors, contributes …

The nuclear-to-cytoplasmic ratio: coupling DNA content to cell size, cell cycle, and biosynthetic capacity

S Balachandra, S Sarkar… - Annual review of genetics, 2022 - annualreviews.org
Though cell size varies between different cells and across species, the nuclear-to-
cytoplasmic (N/C) ratio is largely maintained across species and within cell types. A cell …

Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains

AAW Cramer, V Prasad, E Eftestøl, T Song… - Nature …, 2020 - nature.com
Mammalian cells exhibit remarkable diversity in cell size, but the factors that regulate
establishment and maintenance of these sizes remain poorly understood. This is especially …

Microtubule-based transport is essential to distribute RNA and nascent protein in skeletal muscle

LT Denes, CP Kelley, ET Wang - Nature communications, 2021 - nature.com
While the importance of RNA localization in highly differentiated cells is well appreciated,
basic principles of RNA localization in skeletal muscle remain poorly characterized. Here …

Skeletal muscle memory

AP Sharples, DC Turner - American Journal of Physiology …, 2023 - journals.physiology.org
Skeletal muscle memory is an exciting phenomenon gaining significant traction across
several scientific communities, among exercise practitioners, and the public. Research has …

Differences in muscle satellite cell dynamics during muscle hypertrophy and regeneration

S Fukada, T Higashimoto, A Kaneshige - Skeletal muscle, 2022 - Springer
Skeletal muscle homeostasis and function are ensured by orchestrated cellular interactions
among several types of cells. A noticeable aspect of skeletal muscle biology is the drastic …

Variability in vastus lateralis fiber type distribution, fiber size, and myonuclear content along and between the legs

O Horwath, H Envall, J Röja… - Journal of Applied …, 2021 - journals.physiology.org
Human skeletal muscle characteristics such as fiber type composition, fiber size, and
myonuclear content are widely studied in clinical and sports-related contexts. Being aware …

Lineage tracing of nuclei in skeletal myofibers uncovers distinct transcripts and interplay between myonuclear populations

C Sun, CO Swoboda, FM Morales, C Calvo… - Nature …, 2024 - nature.com
Multinucleated skeletal muscle cells need to acquire additional nuclei through fusion with
activated skeletal muscle stem cells when responding to both developmental and adaptive …

The myonuclear domain in adult skeletal muscle fibres: past, present and future

JR Bagley, LT Denes, JJ McCarthy… - The Journal of …, 2023 - Wiley Online Library
Most cells in the body are mononuclear whereas skeletal muscle fibres are uniquely
multinuclear. The nuclei of muscle fibres (myonuclei) are usually situated peripherally which …