Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
The development of new CRISPR–Cas genome editing tools continues to drive major
advances in the life sciences. Four classes of CRISPR–Cas-derived genome editing agents …
advances in the life sciences. Four classes of CRISPR–Cas-derived genome editing agents …
CRISPR/Cas-mediated base editing: technical considerations and practical applications
Genome editing with CRISPR/Cas has rapidly gained popularity. Base editing, a new
CRISPR/Cas-based approach, can precisely convert one nucleotide to another in DNA or …
CRISPR/Cas-based approach, can precisely convert one nucleotide to another in DNA or …
Precision genome editing using cytosine and adenine base editors in mammalian cells
Genome editing has transformed the life sciences and has exciting prospects for use in
treating genetic diseases. Our laboratory developed base editing to enable precise and …
treating genetic diseases. Our laboratory developed base editing to enable precise and …
The CRISPR/Cas revolution continues: from efficient gene editing for crop breeding to plant synthetic biology
Since the discovery that nucleases of the bacterial CRISPR (clustered regularly interspaced
palindromic repeat)‐associated (Cas) system can be used as easily programmable tools for …
palindromic repeat)‐associated (Cas) system can be used as easily programmable tools for …
碱基编辑系统研究进展
宗媛， 高彩霞 - 遗传, 2019 - chinagene.cn
碱基编辑技术(base editing) 是基于CRISPR/Cas 系统发展起来的新型靶基因修饰技术,
目前依据碱基修饰酶的不同可分为胞嘧啶碱基编辑器(cytosine base editor, CBE) …
目前依据碱基修饰酶的不同可分为胞嘧啶碱基编辑器(cytosine base editor, CBE) …
A panel of eGFP reporters for single base editing by APOBEC-Cas9 editosome complexes
AS Martin, DJ Salamango, AA Serebrenik… - Scientific reports, 2019 - nature.com
The prospect of introducing a single C-to-T change at a specific genomic location has
become feasible with APOBEC-Cas9 editing technologies. We present a panel of eGFP …
become feasible with APOBEC-Cas9 editing technologies. We present a panel of eGFP …
High-throughput and genome-scale targeted mutagenesis using CRISPR in a nonmodel multicellular organism, Bombyx mori
S Ma, T Zhang, R Wang, P Wang, Y Liu… - Genome …, 2024 - genome.cshlp.org
Large-scale genetic mutant libraries are powerful approaches to interrogating genotype–
phenotype correlations and identifying genes responsible for certain environmental stimuli …
phenotype correlations and identifying genes responsible for certain environmental stimuli …
Modeling human point mutation diseases in Xenopus tropicalis with a modified CRISPR/Cas9 system
Z Shi, H Xin, D Tian, J Lian, J Wang, G Liu… - The FASEB …, 2019 - Wiley Online Library
Precise single‐base editing mXenopus tropicalis would greatly expand the utility of this true
diploid frog for modeling human genetic diseases caused by point mutations. Here, we …
diploid frog for modeling human genetic diseases caused by point mutations. Here, we …
Germline Editing of Drosophila Using CRISPR-Cas9-Based Cytosine and Adenine Base Editors
N Thakkar, A Hejzlarova, V Brabec… - The CRISPR Journal, 2023 - liebertpub.com
Target-AID, BE3, and ABE7. 10 base editors fused to the catalytically modified Cas9 and
xCas9 (3.7) were tested for germline editing of the fruit fly Drosophila melanogaster. We …
xCas9 (3.7) were tested for germline editing of the fruit fly Drosophila melanogaster. We …
The novel insight into the outcomes of CRISPR/Cas9 editing intra-and inter-species
J Chang, X Chen, T Zhang, R Wang, A Wang… - International Journal of …, 2020 - Elsevier
The CRISPR/Cas (clustered regularly interspaced short palindromic repeat
technology/CRISPR-associated protein) is a widely used and powerful research tool in …
technology/CRISPR-associated protein) is a widely used and powerful research tool in …