How enhancers activate their distal target promoters remains incompletely understood. Here
we dissect how CTCF-mediated loops facilitate and restrict such regulatory interactions …

Zygotic genome activation (ZGA) marks the beginning of the embryonic program for a
totipotent embryo, which gives rise to the inner cell mass (ICM) where pluripotent epiblast …

The ability of the pluripotent epiblast to contribute progeny to all three germ layers is thought
to be lost after gastrulation. The later-forming neural crest (NC) rises from ectoderm and it …

Mammalian embryogenesis commences with two pivotal and binary cell fate decisions that
give rise to three essential lineages: the trophectoderm, the epiblast and the primitive …

Pioneer transcription factors (TFs), such as OCT4 and SOX2, play crucial roles in
pluripotency regulation. However, the master TF-governed pluripotency regulatory circuitry …

During the first lineage segregation, a mammalian totipotent embryo differentiates into the
inner cell mass (ICM) and trophectoderm (TE). However, how transcription factors (TFs) …

Pioneer factors are a subclass of transcription factors that can bind and initiate opening of
silent chromatin regions. Pioneer factors subsequently regulate lineage-specific genes and …

Here, we describe how the speed of C/EBPα-induced B cell to macrophage
transdifferentiation (BMT) can be regulated, using both mouse and human models. The …

The International Asilomar Chromatin, Chromosomes, and Epigenetics Conference was
held online from 8 to 10 December 2022. Topics of this year's conference included …

Tissue damage elicits cell fate switching through a process called metaplasia, but how the
starting cell fate is silenced and the new cell fate is activated has not been investigated in …