The nuclear receptors REV-ERB (consisting of REV-ERBα and REV-ERBβ) and retinoic acid
receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are …

Many molecular, physiological and behavioural processes display distinct 24-hour rhythms
that are directed by the circadian system. The master clock, located in the suprachiasmatic …

The circadian clock imposes daily rhythms in cell proliferation, metabolism, inflammation
and DNA damage response,. Perturbations of these processes are hallmarks of cancer and …

Pancreatic islet cells derived from human pluripotent stem cells hold great promise for
modeling and treating diabetes. Differences between stem-cell-derived and primary islets …

The incidence of obesity and type 2 diabetes mellitus (T2DM) has risen to epidemic
proportions. The pathophysiology of T2DM is complex and involves insulin resistance …

Most aspects of energy metabolism display clear variations during day and night. This daily
rhythmicity of metabolic functions, including hormone release, is governed by a circadian …

Food intake profoundly affects systemic physiology. A large body of evidence has indicated
a link between food intake and circadian rhythms, and~ 24‐h cycles are deemed essential …

In the past decade, it has become increasingly evident that the circadian clock system plays
an important role in many physiological processes. The circadian clock can be divided into 2 …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Abstract REV-ERBα (NR1D1) is a circadian clock component that functions as a
transcriptional repressor. Due to its role in direct modulation of metabolic genes, REV-ERBα …