Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Luminescent and photofunctional transition metal complexes: From molecular design to diagnostic and therapeutic applications

LCC Lee, KKW Lo - Journal of the American Chemical Society, 2022 - ACS Publications
There has been emerging interest in the exploitation of the photophysical and
photochemical properties of transition metal complexes for diagnostic and therapeutic …

Metallodrugs are unique: Opportunities and challenges of discovery and development

EJ Anthony, EM Bolitho, HE Bridgewater… - Chemical …, 2020 - pubs.rsc.org
Metals play vital roles in nutrients and medicines and provide chemical functionalities that
are not accessible to purely organic compounds. At least 10 metals are essential for human …

Design of superior phototheranostic agents guided by Jablonski diagrams

G Feng, GQ Zhang, D Ding - Chemical Society Reviews, 2020 - pubs.rsc.org
Phototheranostics represents a promising direction for modern precision medicine, which
has recently attracted great research interest from multidisciplinary research areas. Organic …

In response to precision medicine: Current subcellular targeting strategies for cancer therapy

Z Li, J Zou, X Chen - Advanced Materials, 2023 - Wiley Online Library
Emerging as a potent anticancer treatment, subcellular targeted cancer therapy has drawn
increasing attention, bringing great opportunities for clinical application. Here, two targeting …

Metallodrugs in cancer nanomedicine

Q Peña, A Wang, O Zaremba, Y Shi… - Chemical society …, 2022 - pubs.rsc.org
Metal complexes are extensively used for cancer therapy. The multiple variables available
for tuning (metal, ligand, and metal–ligand interaction) offer unique opportunities for drug …

Recent advances in noble metal complex based photodynamic therapy

Y Wu, S Li, Y Chen, W He, Z Guo - Chemical Science, 2022 - pubs.rsc.org
Photodynamic therapy (PDT) utilizes light-activated photosensitizers (PSs) to generate toxic
species for therapeutics. It has become an emerging solution for cancer treatment because …

Visible-light-mediated modification and manipulation of biomacromolecules

VM Lechner, M Nappi, PJ Deneny, S Folliet… - Chemical …, 2021 - ACS Publications
Chemically modified biomacromolecules─ ie, proteins, nucleic acids, glycans, and lipids─
have become crucial tools in chemical biology. They are extensively used not only to …

Ferroptosis‐enhanced cancer immunity by a ferrocene‐appended iridium (III) Diphosphine complex

WJ Wang, YY Ling, YM Zhong, ZY Li… - Angewandte Chemie …, 2022 - Wiley Online Library
Ferroptosis is a programmed cell death pathway discovered in recent years, and ferroptosis‐
inducing agents have great potential as new antitumor candidates. Here, we report a IrIII …

Organelle-targeted photosensitizers for precision photodynamic therapy

R Wang, X Li, J Yoon - ACS Applied Materials & Interfaces, 2021 - ACS Publications
Subcellular organelles are the cornerstones of cells, and destroying them will cause cell
dysfunction and even death. Therefore, realizing precise organelle targeting of …