Recently, inorganic anions and sulphonamides, two of the main classes of zinc-binding
carbonic anhydrase inhibitors (CAIs), were investigated for inhibition of the α-class carbonic …

The bacterial pathogen Neisseria gonorrhoeae encodes for an α-class carbonic anhydrase
(CA, EC 4.2. 1.1), NgCA, which was investigated for its inhibition with a series of inorganic …

The history of Neisseria research has involved the use of a wide variety of vertebrate and
invertebrate animal models, from insects to humans. In this review, we itemise these models …

Neisseria gonorrhoeae exhibits alarming antibiotic resistance trends and poses a significant
challenge in therapeutic management. This study aimed to explore the association of penA …

The lack of effective first-line antibiotic treatments against Neisseria gonorrhoeae, and the
worldwide dissemination of resistant strains, are the main drivers of a worsening global …

Effective treatment of gonorrhea is threatened by the increasing prevalence of Neisseria
gonorrhoeae strains resistant to the extended-spectrum cephalosporins (ESCs). Recently …

Antibiotics are the primary drugs for combating Neisseria gonorrhoeae infections, but with
evolving antibiotic resistance of this bacterium, new druggable molecules are needed to …

The ability to control bacterial infection transformed the practice of medicine. Of the first
antibacterial compounds isolated from Nature nearly a century ago—the gramicidins, the …