Despite decades of accumulated knowledge about proteins and their post-translational
modifications (PTMs), numerous questions remain regarding their molecular composition …

Two-dimensional gel electrophoresis (2DE) is an important and well-established technical
platform enabling extensive top-down proteomic analysis. However, the long-held but now …

X-ray-based analytics are routinely applied in many fields, including physics, chemistry,
materials science, and engineering. The full potential of such techniques in the life sciences …

Many different methods are used for mass-spectrometry-based protein quantification in
pharmacokinetics and systems pharmacology. It has not been established to what extent the …

In surgical oncology, decisions regarding the amount of tissue to be removed can have
important consequences: the decision between preserving sufficient healthy tissue and …

Tissues and biofluids are important sources of information used for the detection of diseases
and decisions on patient therapies. There are several accepted methods for preservation of …

Medulloblastoma (MB), the most prevalent malignant childhood brain tumour, consists of at
least 4 distinct subgroups each of which possesses a unique survival rate and response to …

Abstract Spatially Targeted Mass Spectrometry (MS) analysis using survey scans with an
imaging modality often requires consecutive tissue slices, because of the tissue damage …

Common workflows in bottom-up proteomics require homogenization of tissue samples to
gain access to the biomolecules within the cells. The homogenized tissue samples often …

Osteoporosis is caused by increased bone resorption and decreased bone formation.
Intermittent administration of a fragment of Parathyroid hormone (PTH) activates osteoblast …