In the last two decades we have witnessed sizable progress in defining the role of
gastrointestinal signals in the control of glucose and energy homeostasis. Specifically, the …

The incretin hormones gastric inhibitory polypeptide and especially glucagon-like peptide
(GLP) have an important physiological function in augmenting postprandial insulin …

The intra-islet theory states that glucagon secretion is suppressed when insulin secretion is
stimulated, but glucagon's role in intra-islet paracrine regulation is controversial. This study …

Bile acids are well-recognized stimuli of glucagon-like peptide-1 (GLP-1) secretion. This
action has been attributed to activation of the G protein–coupled bile acid receptor GPBAR1 …

In type-2 diabetes, the overall incretin effect is reduced. The present investigation was
designed to compare insulinotropic actions of exogenous incretin hormones (gastric …

Using specific radioimmunoassays, we studied the occurrence of amidated and glycine-
extended glucagon-like peptide I (GLP-I) molecules in the human small intestine and …

To elucidate the causes of the diminished incretin effect in type 2 diabetes mellitus we
investigated the secretion of the incretin hormones, glucagon-like peptide-1 and glucose …

Glucagon-like peptide 1 (GLP-1) is a hormone derived from the preproglucagon molecule
and is secreted by intestinal L cells. It is the most potent stimulator of glucose-induced …

Abstract Objective Bile acids (BAs) facilitate fat absorption and may play a role in glucose
and metabolism regulation, stimulating the secretion of gut hormones. The relative …

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